Involvement of E2F transcription factor family in cancer

被引：134

作者：

Tsantoulis, PK ^{[1
]}

Gorgoulis, VG ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Dept Histol & Embryol, Mol Carcinogenesis Grp, GR-11146 Athens, Greece

来源：

EUROPEAN JOURNAL OF CANCER | 2005年 / 41卷 / 16期

关键词：

transcription factors; cancer; E2F transcription factors; E2F1 transcription factor; cell cycle; apoptosis; DNA damage; lung cancer; breast tumours; bladder tumours;

D O I：

10.1016/j.ejca.2005.08.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The E2F family of transcription factors is a central modulator of important cellular events, including cell cycle progression, apoptosis and DNA damage response. The role of E2F family members in various human malignancies is yet unclear and may provide vital clues to the diagnosis, prognosis and therapy of cancer patients. In this review we provide a brief but concise overview of E2F function and its putative role in the most common human tumour types. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2403 / 2414

页数：12

共 183 条

[51] Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F [J].

Hershko, T ;

Chaussepied, M ;

Oren, M ;

Ginsberg, D .

CELL DEATH AND DIFFERENTIATION, 2005, 12 (04) :377-383

[52] Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis [J].

Hershko, T ;

Ginsberg, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (10) :8627-8634

[53] Increased levels of E2F-1-dependent DNA binding activity after UV- or γ-irradiation [J].

Höfferer, M ;

Wirbelauer, C ;

Humar, B ;

Krek, W .

NUCLEIC ACIDS RESEARCH, 1999, 27 (02) :491-495

[54] E2F activity is biphasically regulated by androgens in LNCaP cells [J].

Hofman, K ;

Swinnen, JV ;

Verhoeven, G ;

Heyns, W .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 283 (01) :97-101

[55] MULTIPLE DNA ELEMENTS ARE REQUIRED FOR THE GROWTH-REGULATION OF THE MOUSE E2F1 PROMOTER [J].

HSIAO, KM ;

MCMAHON, SL ;

FARNHAM, PJ .

GENES & DEVELOPMENT, 1994, 8 (13) :1526-1537

[56] Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage [J].

Hsieh, JK ;

Yap, D ;

O'Connor, DJ ;

Fogal, V ;

Fallis, L ;

Chan, F ;

Zhong, S ;

Lu, X .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (01) :78-93

[57]

Huang YY, 1997, CANCER RES, V57, P3640

[58]

Humbert PO, 2000, GENE DEV, V14, P690

[59] E2F4 is essential for normal erythrocyte maturation and neonatal viability [J].

Humbert, PO ;

Rogers, C ;

Ganiatsas, S ;

Landsberg, RL ;

Trimarchi, JM ;

Dandapani, S ;

Brugnara, C ;

Erdman, S ;

Schrenzel, M ;

Bronson, RT ;

Lees, JA .

MOLECULAR CELL, 2000, 6 (02) :281-291

[60] Overexpression of E2F1 associated with LOH at RB locus and hyperphosphorylation of RB in non-small cell lung carcinoma [J].

Imai, MA ;

Oda, Y ;

Oda, M ;

Nakanishi, I ;

Kawahara, E .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2004, 130 (06) :320-326

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