Involvement of E2F transcription factor family in cancer

被引：133

作者：

Tsantoulis, PK ^{[1
]}

Gorgoulis, VG ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Dept Histol & Embryol, Mol Carcinogenesis Grp, GR-11146 Athens, Greece

来源：

EUROPEAN JOURNAL OF CANCER | 2005年 / 41卷 / 16期

关键词：

transcription factors; cancer; E2F transcription factors; E2F1 transcription factor; cell cycle; apoptosis; DNA damage; lung cancer; breast tumours; bladder tumours;

D O I：

10.1016/j.ejca.2005.08.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The E2F family of transcription factors is a central modulator of important cellular events, including cell cycle progression, apoptosis and DNA damage response. The role of E2F family members in various human malignancies is yet unclear and may provide vital clues to the diagnosis, prognosis and therapy of cancer patients. In this review we provide a brief but concise overview of E2F function and its putative role in the most common human tumour types. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2403 / 2414

页数：12

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