GlyConnect: Glycoproteomics Goes Visual, Interactive, and Analytical

被引：87

作者：

Alocci, Davide ^{[1
,2
]}

Mariethoz, Julien ^{[1
,2
]}

Gastaldello, Alessandra ^{[1
,2
]}

Gasteiger, Elisabeth ^{[3
]}

Karlsson, Niclas G. ^{[4
]}

Kolarich, Daniel ^{[5
,6
,7
]}

Packer, Nicolle H. ^{[5
,6
,7
,8
]}

Lisacek, Frederique ^{[1
,2
,9
]}

机构：

[1] SIB, Proteome Informat Grp, Rue Michel Servet 1, CH-1211 Geneva, Switzerland

[2] Univ Geneva, Comp Sci Dept, CH-1227 Geneva, Switzerland

[3] SIB, Swiss Prot Grp, CH-1211 Geneva, Switzerland

[4] Univ Gothenburg, Inst Biomed, Dept Med Biochem & Cell Biol, S-40530 Gothenburg, Sweden

[5] Griffith Univ, Inst Glyc, Southport, Qld 4215, Australia

[6] Macquarie Univ, ARC Ctr Nanoscale BioPhoton, Sydney, NSW 2109, Australia

[7] Griffith Univ, Sydney, NSW 2109, Australia

[8] Macquarie Univ, Dept Mol Sci, Sydney, NSW 2109, Australia

[9] Univ Geneva, Sect Biol, CH-1211 Geneva, Switzerland

来源：

JOURNAL OF PROTEOME RESEARCH | 2019年 / 18卷 / 02期

关键词：

data integration; database; software; glycoprotein; glycomics; glycoproteomics; glycan structure; mass spectrometry; data curation; data visualization; SYMBOL NOMENCLATURE; RELATIONAL DATABASE; GLYCOMICS; TOOL; ONTOLOGY;

D O I：

10.1021/acs.jproteome.8b00766

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Knowledge of glycoproteins, their site-specific glycosylation patterns, and the glycan structures that they present to their recognition partners in health and disease is gradually being built on using a range of experimental approaches. The data from these analyses are increasingly being standardized and presented in various sources, from supplemental tables in publications to localized servers in investigator laboratories. Bioinformatics tools are now needed to collect these data and enable the user to search, display, and connect glycomics and glycoproteomics to other sources of related proteomics, genomics, and interactomics information. We here introduce GlyConnect (https://glyconnect.expasy.org/), the central platform of the Glycomics@ExPASy portal for glycoinformatics. GlyConnect has been developed to gather, monitor, integrate, and visualize data in a user-friendly way to facilitate the interpretation of collected glycoscience data. GlyConnect is designed to accommodate and integrate multiple data types as they are increasingly produced.

引用

页码：664 / 677

页数：14

共 47 条

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