Lack of association between the angiotensin-converting enzyme gene (I/D) polymorphism and diabetic nephropathy in Tunisian type 2 diabetic patients

被引：32

作者：

Arfa, Imen ^{[1
]}

Abid, Abdelmajid ^{[3
]}

Nouira, Sonia ^{[1
]}

Elloumi-Zghal, Houda ^{[1
]}

Malouche, Dhafer ^{[2
]}

Mannai, Imen ^{[1
,2
]}

Zorgati, Mohamed Majdi ^{[1
]}

Ben Alaya, Nissaf ^{[4
]}

Rebai, Ahmed

Zouari, Bechir ^{[5
]}

Ben Ammar, Slim ^{[1
]}

Ben Rayana, Mohamed Chiheb ^{[3
]}

Hmida, Slama ^{[6
]}

Blousa-Chabchoub, Samira ^{[3
]}

Abdelhak, Sonia ^{[1
]}

机构：

[1] Inst Pasteur Tunis, Mol Invest Genet Orphan Dis Res Unit, Tunis, Tunisia

[2] Univ 7th November, Engn Sch Stat & Informat Anal, LEGI, EPT, Carthage Tunis, Tunisia

[3] Natl Inst Nutr, Tunis, Tunisia

[4] Inst Pasteur Tunis, Lab Epidemiol, Tunis, Tunisia

[5] Sch Univ Med, Dept Epidemiol & Stat, Tunis, Tunisia

[6] Natl Ctr Blood Transfus, Tunis, Tunisia

来源：

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | 2008年 / 9卷 / 01期

关键词：

anglotensin-converting enzyme; diabetic nephropathy; insertion-deletion polymorphism; type; 2; diabetes;

D O I：

10.3317/jraas.2008.002

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Objective. The aim of the present study was to investigate whether the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with diabetic nephropathy and type 2 diabetes in the Tunisian population. Design. A case-control study was conducted among 141 unrelated type 2 diabetic patients with (90 patients) or without nephropathy (51 patients) and 103 non-diabetic controls with normal fasting blood glucose. Genotyping was performed using a nested polymerase chain reaction amplification in order to identify correctly heterozygous individuals. Results. The distribution of DD, ID and II genotypes did not significantly differ between type 2 diabetic patients with or without nephropathy (DD: 44%; ID: 46%; II: 10% vs. DD: 41%; ID: 47 %; II: 12%, respectively). There was also no significant statistical difference between the genotype distribution and allele frequencies of the (I/D) polymorphism in all type 2 diabetic subjects compared to non-diabetic controls with normal fasting blood glucose (DD: 43%; ID: 46%; II: 11% vs. DD: 37%; ID: 48%; II: 15%, respectively). Conclusions. In the present preliminary study, the (I/D) polymorphism within the ACE gene is likely not associated with diabetic nephropathy nor with type 2 diabetes in the Tunisian studied population.

引用

页码：32 / 36

页数：5

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