Advances in structural design of lipid-based nanoparticle carriers for delivery of macromolecular drugs, phytochemicals and anti-tumor agents

被引：176

作者：

Angelova, Angelina ^{[1
]}

Garamus, Vasil M. ^{[2
]}

Angelov, Borislav ^{[3
]}

Tian, Zhenfen ^{[4
,5
]}

Li, Yawen ^{[4
,5
]}

Zou, Aihua ^{[4
,5
]}

机构：

[1] Univ Paris Saclay, Univ Paris Sud, CNRS UMR 8612, Inst Gallen Paris Sud,LabEx LERMIT, F-92290 Chatenay Malabry, France

[2] Helmholtz Zentrum Geesthacht, Ctr Mat & Coastal Res, D-21502 Geesthacht, Germany

[3] Acad Sci Czech Republ, Inst Phys, ELI Beamlines, Na Slovance 2, CZ-18221 Prague, Czech Republic

[4] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab Funct Mat Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

[5] East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Appl Chem, Shanghai 200237, Peoples R China

来源：

ADVANCES IN COLLOID AND INTERFACE SCIENCE | 2017年 / 249卷

基金：

中国国家自然科学基金;

关键词：

Liquid crystalline nanocarriers; Drug delivery; BioSAXS; Nanostructured lipid carriers; Nanomedicines; Self-assembled biomaterials; X-RAY-SCATTERING; LIQUID-CRYSTALLINE NANOPARTICLES; SMALL-ANGLE NEUTRON; SYNCHROTRON-RADIATION SAXS; IN-VITRO; CO-DELIVERY; PHASE-TRANSITION; SIRNA DELIVERY; CUBIC PHASES; AMPHIPHILE NANOARCHITECTONICS;

D O I：

10.1016/j.cis.2017.04.006

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The present work highlights recent achievements in development of nanostructured dispersions and biocolloids for drug delivery applications. We emphasize the key role of biological small-angle X-ray scattering (BioSAXS) investigations for the nanomedicine design. A focus is given on controlled encapsulation of small molecular weight phytochemical drugs in lipid-based nanocarriers as well as on encapsulation of macromolecular siRNA, plasmid DNA, peptide and protein pharmaceuticals in nanostructured nanoparticles that may provide efficient intracellular delivery and triggered drug release. Selected examples of utilisation of the BioSAXS method for characterization of various types of liquid crystalline nanoorganizations (liposome, spongosome, cubosome, hexosome, and nanostructured lipid carriers) are discussed in view of the successful encapsulation and protection of phytochemicals and therapeutic biomolecules in the hydrophobic or the hydrophilic compartments of the nanocarriers. We conclude that the structural design of the nanoparticulate carriers is of crucial importance for the therapeutic outcome and the triggered drug release from biocolloids.

引用

页码：331 / 345

页数：15

共 177 条

[1] Investigating the cubosomal ability for transnasal brain targeting: In vitro optimization, ex vivo permeation and in vivo biodistribution [J].