Testosterone Deficiency

被引：149

作者：

Traish, Abdulmaged M. ^{[1
,2
]}

Miner, Martin M. ^{[3
]}

Morgentaler, Abraham ^{[4
]}

Zitzmann, Michael ^{[5
]}

机构：

[1] Boston Univ, Sch Med, Dept Biochem, Boston, MA 02118 USA

[2] Boston Univ, Sch Med, Div Urol, Boston, MA 02118 USA

[3] Brown Univ, Dept Family Med & Urol, Warren Albert Sch Med, Providence, RI 02906 USA

[4] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Urol, Boston, MA 02215 USA

[5] Univ Clin Muenster, Ctr Reprod Med & Androl Clin Androl, Munster, Germany

来源：

AMERICAN JOURNAL OF MEDICINE | 2011年 / 124卷 / 07期

关键词：

Cardiovascular disease; Erectile dysfunction; Insulin resistance; Metabolic syndrome; Testosterone; LATE-ONSET HYPOGONADISM; HORMONE-BINDING-GLOBULIN; MIDDLE-AGED MEN; SYMPTOMATIC ANDROGEN DEFICIENCY; CARDIOVASCULAR RISK-FACTORS; ENDOGENOUS SEX-HORMONES; LOW SERUM TESTOSTERONE; NON-HISPANIC WHITES; METABOLIC SYNDROME; INSULIN-RESISTANCE;

D O I：

10.1016/j.amjmed.2010.12.027

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Testosterone deficiency (TD) afflicts approximately 30% of men aged 40-79 years, with an increase in prevalence strongly associated with aging and common medical conditions including obesity, diabetes, and hypertension. A strong relationship is noted between TD and metabolic syndrome, although the relationship is not certain to be causal. Repletion of testosterone (T) in T-deficient men with these comorbidities may indeed reverse or delay their progression. While T repletion has been largely thought of in a sexual realm, we discuss its potential role in general men's health concerns: metabolic, body composition, and all-cause mortality through the use of a single clinical vignette. This review examines a host of studies, with practical recommendations for diagnosis of TD and T repletion in middle-aged and older men, including an analysis of treatment modalities and areas of concerns and uncertainty. (C) 2011 Elsevier Inc. All rights reserved. The American Journal of Medicine (2011) 124, 578-587

引用

页码：578 / 587

页数：10

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