Green metal-free synthesis of spiro-fused 3,4-pyrazolo[4,3:5,6]pyrido[2,3-d]pyrimidine derivatives via deamination cyclization reactions in aqueous medium

被引：9

作者：

Dai, Lei ^{[1
]}

Mao, Kaimin ^{[1
]}

Pan, Zhengbing ^{[1
]}

Rong, Liangce ^{[1
]}

机构：

[1] Jiangsu Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Green Synthet Chem Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2019年 / 45卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Pyrazolo[4 ' 3 ':5,6]pyrido[2,3-d] pyrimidine; Green synthesis; Deamination reaction; Aqueous medium; Spiro compound; ONE-POT SYNTHESIS; 3-COMPONENT REACTION; EFFICIENT SYNTHESIS; CATALYST; SPIROOXINDOLE; INHIBITORS; HETEROCYCLES; DISCOVERY; ACID; NANOPARTICLES;

D O I：

10.1007/s11164-018-3642-3

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A green metal-free synthesis of spiro-fused 3,4-pyrazolo[4,3:5,6]pyrido[2,3-d]pyrimidine derivatives via deamination cyclization reactions of isatins, substituted 1H-pyrazol-5-amine, and 6-aminopyrimidine-2,4(1H,3H)-dione or 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione in aqueous medium is reported. This is an efficient route for synthesis of the target products by deamination cyclization reaction. The other advantages of this process are high yield, easy separation, wide substrate range, and environmental friendliness.

引用

页码：769 / 788

页数：20

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