Update on endothelial dysfunction in COVID-19: severe disease, long COVID-19 and pediatric characteristics

被引：14

作者：

Gavriilaki, Eleni ^{[3
]}

Eftychidis, Ioannis ^{[3
]}

Papassotiriou, Ioannis ^{[1
,2
]}

机构：

[1] Aghia Sophia Childrens Hosp Athens, Dept Clin Biochem, Athens, Greece

[2] Emerging Technol Pediat Lab Med C ETPLM, IFCC Emerging Technol Div, Milan, Italy

[3] G Papanikolaou Hosp, BMT Unit, Hematol Dept, Thessaloniki, Greece

来源：

JOURNAL OF LABORATORY MEDICINE | 2021年 / 45卷 / 06期

关键词：

COVID-19; endothelial dysfunction; long COVID-19; pediatric; SARS-COV-2; thrombosis; ACUTE RESPIRATORY SYNDROME; VON-WILLEBRAND-FACTOR; VENOUS THROMBOEMBOLIC EVENTS; ACUTE LIMB ISCHEMIA; P-SELECTIN; SYNDROME CORONAVIRUS; VIRAL-INFECTIONS; SYNDROME SARS; MECHANISMS; PATHOLOGY;

D O I：

10.1515/labmed-2021-0134

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objectives: To review current literature on the role of endothelial dysfunction in coronavirus disease-2019 (COVID-19) infection in terms of pathophysiology, laboratory features and markers, clinical phenotype in adults and children, as well as long COVID-19. Content: We conducted a thorough assessment of the literature and critically analyzed current data, mostly utilizing the PubMed and Medline search engines to find original studies published in the previous decade. Summary and Outlook: Accumulating evidence suggests that endothelial dysfunction may be a common denominator of severe COVID-19 in adults and children, as well as long COVID-19, implicating mutual pathophysiological pathways. This narrative review summarizes the up-to-date knowledge of endothelial dysfunction caused by COVID-19, including novel aspects of long COVID-19 and pediatric disease. This knowledge is important in order not only to understand the multisystemic attack of COVID-19, but also to improve patient management and prognosis.

引用

页码：293 / 302

页数：10

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