A Carbazole-Fused-RhodamineProbe for Detection of HOCl in Living Cells

被引：6

作者：

Guo, Rui ^{[1
]}

Wang, Qiuan ^{[1
]}

Lin, Weiying ^{[1
,2
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

[2] Univ Jinan, Inst Fluorescent Probes Biol Imaging, Sch Chem & Chem Engn, Sch Mat Sci & Engn, Jinan 250022, Shandong, Peoples R China

来源：

JOURNAL OF FLUORESCENCE | 2017年 / 27卷 / 06期

关键词：

Fluorescent probe; Carbazole; Rhodamine; HOCl; CHROMATOGRAPHY-MASS-SPECTROMETRY; HYPOCHLORITE-INDUCED OXIDATION; FLUORESCENT-PROBE; ACID; MYELOPEROXIDASE; CHEMOSENSORS; RADICALS; INFLAMMATION; PRODUCTS; PROTEINS;

D O I：

10.1007/s10895-017-2134-y

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel fluorescent probe CR-ClO for detection of HOCl based on a carbazole fused rhodamine was designed and synthesized. The probe utilized a HOCl-promoted oxidation reaction, which lead to the ring opening of the compound with a strong enhancement of the fluorescent emission at about 587 nm.The new probe CR-ClO has excellent selectivity and high sensitivity to ClO-,whose detection limit to ClO- is 1.16 x 10(-6) M. Furthermore, the new probe has been successfully applied in living cells for detection of ClO-.

引用

页码：1969 / 1974

页数：6

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