Fractionation of Azaphilones from Secondary Metabolites of Marine-Derived Fungus Penicillim pinophilum and Their Antibacterial Activity

被引：8

作者：

Ma Yangyang ^{[1
]}

Cai Hui ^{[1
]}

Du Min ^{[1
]}

Cao Fei ^{[1
]}

Zhu Huajie ^{[1
]}

机构：

[1] Hebei Univ, Coll Pharmaceut Sci, Key Lab Med Chem & Mol Diag, Key Lab Pharmaceut Qual Control Hebei Prov,Minist, Baoding 071002, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2017年 / 38卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Marine. derived fungus; Penicillium pinophilum; Azaphilone derivative; Absolute configuration; Antibacterial activity; STEREOCHEMISTRY; DERIVATIVES;

D O I：

10.7503/cjcu20170304

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bioassay-guide fractionation of the marine. derived fungus Penicillim pinophilum led to the isolation of three azaphilones derivatives: Pinophilins G(1), Pinophilins B(2) and Sch 725680(3), which were separated by silica gel column chromatography, octadecylsilyl(ODS) column chromatography, Sephadex LH-20. Compound 1 is a new compound. The plane structure of compound 1 was determined based on HR-ESI-MS, H-1 NMR, C-13 NMR, heteronuclear multiple bond correlation(HMBC), nuclear overhauser effect spec. troscopy(NOSEY) and heteronuclear singular quantum correlation(HSQC). The absolute configuration of compound 1 was determined by comparing its experimental electronic circular dichroism(ECD) with the calculated ECD spectra using quantum methods. The results indicated that compounds 1 and 3 showed antibacterial activities against four spices of pathogenic bacteria.

引用

页码：1963 / 1967

页数：5

共 21 条

[1] DENSITY FUNCTIONAL GAUSSIAN-TYPE-ORBITAL APPROACH TO MOLECULAR GEOMETRIES, VIBRATIONS, AND REACTION ENERGIES [J].