Leishmania chagasi: Effect of the iron deficiency on the infection in BALB/c mice

被引：14

作者：

Malafaia, Guilherme ^{[1
]}

Marcon, Leticia de Nadai ^{[2
]}

Pereira, Liliane de Fatima

Pedrosa, Maria Lucia ^{[3
]}

Rezende, Simone Aparecida ^{[4
]}

机构：

[1] NPCAB, Inst Fed Educ Ciencia & Tecnol Goiano, Dept Ciencias Biol, Lab Ciencias Ambientais, BR-75790000 Urutai, Go, Brazil

[2] Univ Fed Ouro Preto, Programa Posgrad Ciencias Biol, Lab Imunoparasitol, BR-35400000 Ouro Preto, MG, Brazil

[3] Univ Fed Ouro Preto, Programa Posgrad Ciencias Biol, Nucleo Pesquisa Ciencias Biol NUPEB, Lab Bioquim & Biol Mol,Dept Ciencias Biol, BR-35400000 Ouro Preto, MG, Brazil

[4] Univ Fed Ouro Preto, Programa Posgrad Ciencias Biol, Nucleo Pesquisa Ciencias Biol NUPEB, Lab Imunoparasitol,Dept Anal Clin,Escola Farm, BR-35400000 Ouro Preto, MG, Brazil

来源：

EXPERIMENTAL PARASITOLOGY | 2011年 / 127卷 / 03期

关键词：

Leishmania chagasi; Iron deficiency; BALB/c; Visceral leishmaniasis; Hemoglobin; IFN-gamma; IL-4; CHELATOR DESFERRIOXAMINE; TRYPANOSOMA-CRUZI;

D O I：

10.1016/j.exppara.2010.11.010

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Iron deficiency and visceral leishmaniasis are serious problems of public health. The aim of this study was to evaluate the effect of iron deficiency, induced by the iron chelator desferrioxamine, on the course of the infection by Leishmania chagasi in BALB/c mice. Our data show that the iron chelator caused significant reduction in hemoglobin concentration of treated mice and reduction in parasite load in spleen and liver. Significant differences were not observed in the production of IFN-gamma and IL-4 among the experimental groups. In conclusion, the data reported in this paper suggest that iron deficiency may favor the host. If there is not enough iron available to the parasite, its multiplication may be reduced and infection attenuated. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：719 / 723

页数：5

共 23 条

[1] IMMUNE-RESPONSES ASSOCIATED WITH SUSCEPTIBILITY OF C57BL/10 MICE TO LEISHMANIA-AMAZONENSIS [J].

AFONSO, LCC ;

SCOTT, P .

INFECTION AND IMMUNITY, 1993, 61 (07) :2952-2959

[2]

[Anonymous], 2008, WORLDW PREV AN 1993

[3]

[Anonymous], GUID CAR US EXP AN

[4] Trypanosoma cruzi:: Treatment with the iron chelator desferrioxamine reduces parasitemia and mortality in experimentally infected mice [J].

Arantes, Jerusa Marilda ;

Pedrosa, Maria Lucia ;

Martins, Helen Rodrigues ;

Veloso, Vanja Maria ;

de lana, Marta ;

Bahia, Maria Terezinha ;

Tafuri, Washington Luiz ;

Carneiro, Claudia Martins .

EXPERIMENTAL PARASITOLOGY, 2007, 117 (01) :43-50

[5]

*CAN COUNC AN CAR, 1980, GUID CAR US EXP AN

[6] Heme as a source of iron to Leishmania infantum amastigotes [J].

Carvalho, Sandra ;

Cruz, Tania ;

Santarem, Nuno ;

Castro, Helena ;

Costa, Vitor ;

Tomas, Ana M. .

ACTA TROPICA, 2009, 109 (02) :131-135

[7]

Cook J, 1999, Arch Latinoam Nutr, V49, p11S

[8]

Cook James D., 1992, Nutrition Research Reviews, V5, P189, DOI 10.1079/NRR19920014

[9] Leishmania donovani depletes labile iron pool to exploit iron uptake capacity of macrophage for its intracellular growth [J].

Das, Nupur Kanti ;

Biswas, Sudipta ;

Solanki, Sunil ;

Mukhopadhyay, Chinmay K. .

CELLULAR MICROBIOLOGY, 2009, 11 (01) :83-94

[10] Trypanosoma cruzi: Effect of benznidazole therapy combined with the iron chelator desferrioxamine in infected mice [J].

Francisco, Amanda Fortes ;

de Abreu Vieira, Paula Melo ;

Arantes, Jerusa Marilda ;

Pedrosa, Maria Lucia ;

Martins, Helen Rodrigues ;

Silva, Maisa ;

Veloso, Vanja Maria ;

de Lana, Marta ;

Bahia, Maria Terezinha ;

Tafuri, Washington Luiz ;

Carneiro, Claudia Martins .

EXPERIMENTAL PARASITOLOGY, 2008, 120 (04) :314-319

← 1 2 3 →