Leishmania chagasi: Effect of the iron deficiency on the infection in BALB/c mice

被引：14
|
作者：
Malafaia, Guilherme [1 ]
Marcon, Leticia de Nadai [2 ]
Pereira, Liliane de Fatima
Pedrosa, Maria Lucia [3 ]
Rezende, Simone Aparecida [4 ]
机构：
[1] NPCAB, Inst Fed Educ Ciencia & Tecnol Goiano, Dept Ciencias Biol, Lab Ciencias Ambientais, BR-75790000 Urutai, Go, Brazil
[2] Univ Fed Ouro Preto, Programa Posgrad Ciencias Biol, Lab Imunoparasitol, BR-35400000 Ouro Preto, MG, Brazil
[3] Univ Fed Ouro Preto, Programa Posgrad Ciencias Biol, Nucleo Pesquisa Ciencias Biol NUPEB, Lab Bioquim & Biol Mol,Dept Ciencias Biol, BR-35400000 Ouro Preto, MG, Brazil
[4] Univ Fed Ouro Preto, Programa Posgrad Ciencias Biol, Nucleo Pesquisa Ciencias Biol NUPEB, Lab Imunoparasitol,Dept Anal Clin,Escola Farm, BR-35400000 Ouro Preto, MG, Brazil
来源：
EXPERIMENTAL PARASITOLOGY | 2011年 / 127卷 / 03期
关键词：
Leishmania chagasi; Iron deficiency; BALB/c; Visceral leishmaniasis; Hemoglobin; IFN-gamma; IL-4; CHELATOR DESFERRIOXAMINE; TRYPANOSOMA-CRUZI;
D O I：
10.1016/j.exppara.2010.11.010
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Iron deficiency and visceral leishmaniasis are serious problems of public health. The aim of this study was to evaluate the effect of iron deficiency, induced by the iron chelator desferrioxamine, on the course of the infection by Leishmania chagasi in BALB/c mice. Our data show that the iron chelator caused significant reduction in hemoglobin concentration of treated mice and reduction in parasite load in spleen and liver. Significant differences were not observed in the production of IFN-gamma and IL-4 among the experimental groups. In conclusion, the data reported in this paper suggest that iron deficiency may favor the host. If there is not enough iron available to the parasite, its multiplication may be reduced and infection attenuated. (C) 2010 Elsevier Inc. All rights reserved.
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收藏
页码：719 / 723
页数：5
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