Plasma visfatin level in women with polycystic ovary syndrome

被引:27
作者
Dikmen, Emre [2 ]
Tarkun, Ilhan [1 ]
Canturk, Zeynep [1 ]
Cetinarslan, Berrin [1 ]
机构
[1] Kocaeli Univ, Dept Endocrinol & Metab, Fac Med, Kocaeli, Turkey
[2] Kocaeli Univ, Dept Internal Med, Fac Med, Kocaeli, Turkey
关键词
Visfatin; PCOS; insulin resistance; IMPAIRED GLUCOSE-TOLERANCE; TYPE-2; DIABETES-MELLITUS; COLONY-ENHANCING FACTOR; INSULIN-RESISTANCE; SERUM VISFATIN; OBESE WOMEN; ADIPOCYTES; EXPRESSION; MARKERS; HUMANS;
D O I
10.3109/09513590.2010.495796
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. The aim of this study is to compare the serum level of visfatin between patients with polycystic ovary syndrome (PCOS) and control subjects matched for age and body mass index (BMI) and to assess the possible correlations of visfatin to the hormonal and metabolic parameters of the syndrome. Material and method. aEuro integral Fifty-five patients with PCOS diagnosis composed of 25 obese, 13 overweight, 17 normal weight subjects and 49 women without concomitant disease matched for age and BMI were included in this study. Results. aEuro integral Serum visfatin levels were similar in normal weight PCOS and control group. Visfatin levels in obese and overweight patients with PCOS were higher than that found in control women with similar BMI, and visfatin had positive linear correlation with BMI, waist circumference and HOMA-IR. Obese women with PCOS had also significantly higher visfatin levels than normal weight women with PCOS. Conclusion. aEuro integral Visfatin levels in obese and overweight patients with PCOS were higher than that found in females without concomitant disease with similar BMI, and visfatin had positive linear correlation with BMI, waist circumference and HOMA-IR.
引用
收藏
页码:475 / 479
页数:5
相关论文
共 19 条
[1]   Plasma visfatin concentrations and fat depot-specific mRNA expression in humans [J].
Berndt, J ;
Klöting, N ;
Kralisch, S ;
Kovacs, P ;
Fasshauer, M ;
Schön, MR ;
Stumvoll, M ;
Blüher, M .
DIABETES, 2005, 54 (10) :2911-2916
[2]   Increased plasma visfatin concentrations in women with polycystic ovary syndrome [J].
Chan, Te-Fu ;
Chen, Yi-Ling ;
Chen, Hung-Hseng ;
Lee, Chien-Hung ;
Jong, Shiang-Bin ;
Tsai, Eing-Mei .
FERTILITY AND STERILITY, 2007, 88 (02) :401-405
[3]   Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus [J].
Chen, MP ;
Chung, FM ;
Chang, DM ;
Tsai, JCR ;
Huang, HF ;
Shin, SJ ;
Lee, YJ .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (01) :295-299
[4]   Plasma visfatin levels in patients with newly diagnosed and untreated type 2 diabetes mellitus and impaired glucose tolerance [J].
Dogru, Teoman ;
Sonmez, Alper ;
Tasci, Ilker ;
Bozoglu, Ergun ;
Yilmaz, Mahmut Ilker ;
Genc, Halil ;
Erdem, Gokhan ;
Gok, Mahmut ;
Bingol, Necati ;
Kilic, Selim ;
Ozgurtas, Taner ;
Bingol, Sezin .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2007, 76 (01) :24-29
[5]   Insulin action in thee polycystic ovary syndrome [J].
Dunaif, A .
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 1999, 28 (02) :341-+
[6]   Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis [J].
Dunaif, A .
ENDOCRINE REVIEWS, 1997, 18 (06) :774-800
[7]   Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome [J].
Ehrmann, DA ;
Barnes, RB ;
Rosenfield, RL ;
Cavaghan, MK ;
Imperial, J .
DIABETES CARE, 1999, 22 (01) :141-146
[8]   RETRACTED: Visfatin: A protein secreted by visceral fat that mimics the effects of insulin (Retracted article, see vol 318, pg 565, 2007) [J].
Fukuhara, A ;
Matsuda, M ;
Nishizawa, M ;
Segawa, K ;
Tanaka, M ;
Kishimoto, K ;
Matsuki, Y ;
Murakami, M ;
Ichisaka, T ;
Murakami, H ;
Watanabe, E ;
Takagi, T ;
Akiyoshi, M ;
Ohtsubo, T ;
Kihara, S ;
Yamashita, S ;
Makishima, M ;
Funahashi, T ;
Yamanaka, S ;
Hiramatsu, R ;
Matsuzawa, Y ;
Shimomura, I .
SCIENCE, 2005, 307 (5708) :426-430
[9]   Plasma visfatin level in lean women with PCOS: relation to proinflammatory markers and insulin resistance [J].
Gen, Ramazan ;
Akbay, Esen ;
Muslu, Necati ;
Sezer, Kerem ;
Cayan, Filiz .
GYNECOLOGICAL ENDOCRINOLOGY, 2009, 25 (04) :241-245
[10]   Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding [J].
Haider, DG ;
Schindler, K ;
Schaller, G ;
Prager, G ;
Wolzt, M ;
Ludvik, B .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (04) :1578-1581