Management of ABO-Incompatible Living-Donor Liver Transplantation: Past and Present Trends

被引：76
作者：
Raut, Vikram [1 ]
Uemoto, Shinji [1 ]
机构：
[1] Kyoto Univ, Grad Sch Med, Dept Hepatobiliary Pancreat Surg & Transplantat, Sakyo Ku, Kyoto 6068507, Japan
来源：
SURGERY TODAY | 2011年 / 41卷 / 03期
关键词：
Living-donor liver transplantation; ABO-incompatible; Rituximab; ANTI-CD20; MONOCLONAL-ANTIBODY; BLOOD-GROUP BARRIERS; INFUSION THERAPY; PLASMA-EXCHANGE; MEDIATED REJECTION; RITUXIMAB; SPLENECTOMY; ALLOGRAFTS; PROTOCOL; JAPAN;
D O I：
10.1007/s00595-010-4437-3
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Based on the concept that the liver is a "privileged organ," which resists acute rejection, Thomas Starzl introduced liver transplantation across the ABO blood group. However, with improved survival after liver transplantation came reports of an increased incidence of acute rejection, biliary and vascular complications, and decreased survival after ABO-incompatible liver transplantation. As a result, ABO-incompatible liver transplantations are performed only in emergencies when ABO-compatible grafts are unavailable. In living-donor liver transplantation (LDLT), donors are restricted to family members; therefore, breaking ABO blood group barriers becomes inevitable. This inevitable situation has forced liver transplant surgeons to exploit many innovative techniques to overcome the challenges of ABO-incompatible liver transplantation. This review looks at the history and current practices of ABO-incompatible LDLT to provide insight so that the protocol can be improved further.
引用
收藏
页码：317 / 322
页数：6
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