Determination of Amoxicillin with Novel Rhodanine Ramification by Flow Injection Chemiluminescence

被引：0

作者：

Yu Jing-hua ^{[1
]}

Wan Fu-wei ^{[1
,2
]}

Dai Ping ^{[1
]}

Huang Jia-dong

Cui Jian-jie ^{[1
]}

机构：

[1] Univ Jinan, Coll Chem & Chem Engn, Jinan 250022, Peoples R China

[2] Univ Jinan, Sch Mat & Sci Engn, Jinan 250022, Peoples R China

来源：

2009 3RD INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL ENGINEERING, VOLS 1-11 | 2009年

关键词：

Chemiluminescence; Flow injection; Rhodanine; Amoxicillin;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

3-(4'-fluorophenyl)-5-(2'-sulfonylphenylazo)-rhodanine (4FRASP) firstly synthesized by the authors was used as chemiluminescence (CL) reagent. In acidic medium, CL was observed when amoxicillin was injected into the mixture of 4FRASP-potassium permanganate. Based on this phenomenon, a flow injection CL method was established for the determination of amoxicillin. The CL intensity was correlated linear with the concentration of amoxicillin over the range of 5.0x10(-8) to 2.0x10(-8) g.mL(-1) and the detection limit was 4.5x10(-9) g.mL(-1). The relative standard deviation (RSD) was 1.3 % for determination of 1.0x10(-6) g.mL(-1) amoxicillin (n=11). This method was applied to the determination of amoxicillin in amoxicillin capsules successfully.

引用

页码：4405 / +

页数：2

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