Lead induced oxidative stress: Beneficial effects of Kombucha tea

被引：0

作者：

Dipti, P ^{[1
]}

Yogesh, B ^{[1
]}

Kain, AK ^{[1
]}

Pauline, T ^{[1
]}

Anju, B ^{[1
]}

Sairam, M ^{[1
]}

Singh, B ^{[1
]}

Mongia, SS ^{[1
]}

Kumar, GID ^{[1
]}

Selvamurthy, W ^{[1
]}

机构：

[1] Def Inst Physiol & Allied Sci, Delhi 110054, India

来源：

BIOMEDICAL AND ENVIRONMENTAL SCIENCES | 2003年 / 16卷 / 03期

关键词：

lead; oxidative stress; Kombucha tea; antioxidant activity;

D O I：

暂无

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Objective To evaluate the effect of oral administration of Kombucha tea (K-tea) on lead nduced oxidative stress. Methods Sprague Dawley rats were administered 1 mL of 3.8% lead acetate solution daily alone or in combination with K-tea orally for 45 d, and the antioxidant status and lipid peroxidation were evaluated. Results Oral administration of lead acetate to rats enhanced lipid peroxidation and release of creatine phosphokinase and decreased levels of reduced glutathione (GSH) and antioxidant enzymes (superoxide dismutase, SOD and glutathione peroxidase, GPx). Lead treatment did not alter Immoral immunity, but inhibited DTH response when compared to the control. Lead administration also increased DNA fragmentation in liver. Oral administration of Kombucha tea to rats exposed to lead decreased lipid peroxidation and DNA damage with a concomitant increase in the reduced glutathione level and GPx activity. Kombucha tea supplementation relieved the lead induced immunosuppression to appreciable levels. Conclusion The results suggest that K-tea has potent antioxidant and immunomodulating properties.

引用

页码：276 / 282

页数：7

共 32 条

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