Protein disulfide isomerases are promising targets for predicting the survival and tumor progression in glioma patients

被引：29

作者：

Peng, Zhigang ^{[1
]}

Chen, Yu ^{[2
]}

Cao, Hui ^{[3
]}

Zou, Hecun ^{[4
]}

Wan, Xin ^{[1
]}

Zeng, Wenjing ^{[4
]}

Liu, Yanling ^{[4
]}

Hu, Jiaqing ^{[5
]}

Zhang, Nan ^{[6
]}

Xia, Zhiwei ^{[6
]}

Liu, Zhixiong ^{[1
,7
]}

Cheng, Quan ^{[1
,4
,8
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China

[2] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450001, Henan, Peoples R China

[3] Hunan Univ Chinese Med, Affiliated Hosp, Peoples Hosp Hunan Prov 2, Dept Psychiat, Changsha 410007, Hunan, Peoples R China

[4] Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China

[5] Hunan Univ Chinese Med, Affiliated Hosp, Peoples Hosp Hunan Prov 2, Dept Emergency, Changsha 410007, Hunan, Peoples R China

[6] Harbin Med Univ, Sch Bioinformat Sci & Technol, Harbin 150081, Heilongjiang, Peoples R China

[7] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China

[8] Cent South Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Hunan, Peoples R China

来源：

AGING-US | 2020年 / 12卷 / 03期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

PDI family; PDI; GBM; glioma; prognosis; CLINICALLY RELEVANT SUBTYPES; REPORT PRIMARY BRAIN; DOWN-REGULATION; UNITED-STATES; CANCER; INHIBITION; EXPRESSION; DISCOVERY; TEMOZOLOMIDE; RESISTANCE;

D O I：

10.18632/aging.102748

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The present study focused on the expression patterns, prognostic values and potential mechanism of the PDI family in gliomas. Most PDI family members' mRNA expressions were observed significantly different between gliomas classified by clinical features. Construction of the PDI signature, cluster and risk score models of glioma was done using GSVA, consensus clustering analysis, and LASSO Cox regression analysis respectively. High values of PDI signature/ risk score and cluster 1 in gliomas were associated with malignant clinicopathological characteristics and poor prognosis. Analysis of the distinctive genomic alterations in gliomas revealed that many cases having high PDI signature and risk score were associated with genomic aberrations of driver oncogenes. GSVA analysis showed that PDI family was involved in many signaling pathways in ERAD, apoptosis, and MHC class I among many more. Prognostic nomogram revealed that the risk score was a good prognosis indicator for gliomas. The qRT-PCR and immunohistochemistry confirmed that P4HB, PDIA4 and PDIA5 were overexpressed in gliomas. In summary, this research highlighted the clinical importance of PDI family in tumorigenesis and progression in gliomas.

引用

页码：2347 / 2372

页数：26

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