Hepatitis A Virus Genome Organization and Replication Strategy

被引：63

作者：

McKnight, Kevin L. ^{[1
]}

Lemon, Stanley M.

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Med, Chapel Hill, NC 27599 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2018年 / 8卷 / 12期

关键词：

5 NONTRANSLATED REGION; CAP-INDEPENDENT TRANSLATION; RIBOSOME ENTRY SITE; PYRIMIDINE-RICH TRACT; CELL-CULTURE; IN-VITRO; BINDING-PROTEIN; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; EXTRACELLULAR VESICLES; 5-NONTRANSLATED RNA;

D O I：

10.1101/cshperspect.a033480

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Hepatitis A virus (HAV) is a positive-strand RNA virus classified in the genus Hepatovirus of the family Picornaviridae. It is an ancient virus with a long evolutionary history and multiple features of its capsid structure, genome organization, and replication cycle that distinguish it from other mammalian picornaviruses. HAV proteins are produced by cap-independent translation of a single, long open reading frame under direction of an inefficient, upstream internal ribosome entry site (IRES). Genome replication occurs slowly and is noncytopathic, with transcription likely primed by a uridylated protein primer as in other picornaviruses. Newly produced quasi-enveloped virions (eHAV) are released from cells in a nonlytic fashion in a unique process mediated by interactions of capsid proteins with components of the host cell endosomal sorting complexes required for transport (ESCRT) system.

引用

页数：18

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