Oxytocin plays an important role in the modulation of social behavior in both typical and atypical contexts. Also, the quality of early parental care sets the foundation for long-term psychosocial development. Here, we review studies that investigated how oxytocin receptor (OXTR) interacts with early parental care experiences to influence the development of psychiatric disorders. Using Pubmed, Scopus and PsycInfo databases, we utilized the keyword "OXTR" before subsequently searching for specific OXTR single nucleotide polymorphisms (SNPs), generating a list of 598 studies in total. The papers were catalogued in a database and filtered for gene-environment interaction, psychiatric disorders and involvement of parental care. In particular, rs53576 and rs2254298 were found to be significantly involved in gene-environment interactions that modulated risk for psychopathology and the following psychiatric disorders: disruptive behavior, depression, anxiety, eating disorder and borderline personality disorder. These results illustrate the importance of OXTR in mediating the impact of parental care on the emergence of psychopathology.
机构:
Laureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Univ Tulsa, Sch Community Med, 800 S Tucker Dr, Tulsa, OK 74104 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Aupperle, Robin L.
;
Morris, Amanda S.
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机构:
Laureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Oklahoma State Univ, Dept Human Dev & Family Sci, 700 N Greenwood Ave, Tulsa, OK 74106 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Morris, Amanda S.
;
Silk, Jennifer S.
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Univ Pittsburgh, Dept Psychol, 210 South Bouquet St, Pittsburgh, PA 15260 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Silk, Jennifer S.
;
Criss, Michael M.
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h-index: 0
机构:
Oklahoma State Univ, Dept Human Dev & Family Sci, 700 N Greenwood Ave, Tulsa, OK 74106 USA
Oklahoma State Univ, Ctr Family Resilience, 700 N Greenwood Ave, Tulsa, OK 74106 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Criss, Michael M.
;
Judah, Matt R.
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Oklahoma State Univ, Dept Psychol, 116 N Murray Hall, Stillwater, OK 74078 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Judah, Matt R.
;
Eagleton, Sally G.
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机构:
Oklahoma State Univ, Dept Human Dev & Family Sci, 700 N Greenwood Ave, Tulsa, OK 74106 USA
Oklahoma State Univ, Ctr Family Resilience, 700 N Greenwood Ave, Tulsa, OK 74106 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Eagleton, Sally G.
;
Kirlic, Namik
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h-index: 0
机构:
Laureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Univ Tulsa, Dept Psychol, 800 S Tucker Dr, Tulsa, OK 74104 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Kirlic, Namik
;
Byrd-Craven, Jennifer
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Oklahoma State Univ, Dept Psychol, 116 N Murray Hall, Stillwater, OK 74078 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Byrd-Craven, Jennifer
;
Phillips, Raquel
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Laureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Phillips, Raquel
;
Alvarez, Ruben P.
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h-index: 0
机构:
Laureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Univ Tulsa, Sch Community Med, 800 S Tucker Dr, Tulsa, OK 74104 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
机构:
Laureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Univ Tulsa, Sch Community Med, 800 S Tucker Dr, Tulsa, OK 74104 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Aupperle, Robin L.
;
Morris, Amanda S.
论文数: 0引用数: 0
h-index: 0
机构:
Laureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Oklahoma State Univ, Dept Human Dev & Family Sci, 700 N Greenwood Ave, Tulsa, OK 74106 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Morris, Amanda S.
;
Silk, Jennifer S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Dept Psychol, 210 South Bouquet St, Pittsburgh, PA 15260 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Silk, Jennifer S.
;
Criss, Michael M.
论文数: 0引用数: 0
h-index: 0
机构:
Oklahoma State Univ, Dept Human Dev & Family Sci, 700 N Greenwood Ave, Tulsa, OK 74106 USA
Oklahoma State Univ, Ctr Family Resilience, 700 N Greenwood Ave, Tulsa, OK 74106 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Criss, Michael M.
;
Judah, Matt R.
论文数: 0引用数: 0
h-index: 0
机构:
Oklahoma State Univ, Dept Psychol, 116 N Murray Hall, Stillwater, OK 74078 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Judah, Matt R.
;
Eagleton, Sally G.
论文数: 0引用数: 0
h-index: 0
机构:
Oklahoma State Univ, Dept Human Dev & Family Sci, 700 N Greenwood Ave, Tulsa, OK 74106 USA
Oklahoma State Univ, Ctr Family Resilience, 700 N Greenwood Ave, Tulsa, OK 74106 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Eagleton, Sally G.
;
Kirlic, Namik
论文数: 0引用数: 0
h-index: 0
机构:
Laureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Univ Tulsa, Dept Psychol, 800 S Tucker Dr, Tulsa, OK 74104 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Kirlic, Namik
;
Byrd-Craven, Jennifer
论文数: 0引用数: 0
h-index: 0
机构:
Oklahoma State Univ, Dept Psychol, 116 N Murray Hall, Stillwater, OK 74078 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Byrd-Craven, Jennifer
;
Phillips, Raquel
论文数: 0引用数: 0
h-index: 0
机构:
Laureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Phillips, Raquel
;
Alvarez, Ruben P.
论文数: 0引用数: 0
h-index: 0
机构:
Laureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA
Univ Tulsa, Sch Community Med, 800 S Tucker Dr, Tulsa, OK 74104 USALaureate Inst Brain Res, 6655 S Yale Ave, Tulsa, OK 74136 USA