First total synthesis of marine alkaloid hyrtiosulawesine

被引：13

作者：

Zhang, Pu Yong ^{[1
]}

Wan, Sheng Biao ^{[1
]}

Ren, Su Mei ^{[1
]}

Jiang, Tao ^{[1
]}

机构：

[1] Ocean Univ China, Minist Educ, Key Lab Marine Drugs, Sch Med & Pharm, Qingdao 266003, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 11期

关键词：

beta-Carboline; Hyrtiosulawesine; Pictet-Spengler reaction; Tryptamine; Total synthesis; EUDISTOMIN-U; ISOEUDISTOMIN-U; DERIVATIVES;

D O I：

10.1016/j.cclet.2010.05.012

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hyrtiosulawesine was isolated from Indonesian specimens of the marine sponges Hyrtios erectus and H. reticulatu in 2002. We report here the first total synthesis of hyrtiosulawesine using an efficient and convenient synthetic strategy which could be widely used in the synthesis of other beta-caboline compounds. All structures of new compounds were confirmed by (1)H NMR, (13)C NMR and HRMS. (C) 2010 Tao Jiang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

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页码：1307 / 1309

页数：3

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