The Inhibition of Inflammatory Signaling Pathway by Secretory Leukocyte Protease Inhibitor can Improve Spinal Cord Injury

被引:29
作者
Tang, Renzhe [1 ]
Botchway, Benson O. A. [2 ]
Meng, Yanfeng [3 ]
Zhang, Yong [1 ]
Zhou, Conghui [1 ]
Jiang, Junsong [1 ]
Liu, Xuehong [1 ]
机构
[1] Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing, Peoples R China
[2] Zhejiang Univ, Inst Neurosci, Sch Med, Hangzhou, Peoples R China
[3] Shaoxing Univ, Affiliated Hosp, Dept Orthoped, Shaoxing, Peoples R China
关键词
Ecretory leukocyte protease inhibitor; Spinal cord injury; Nuclear factor kappa beta signaling pathway; Inflammation; Oxidative stress; MESSENGER-RNA EXPRESSION; SLPI; APOPTOSIS; HEAD; PHOSPHORYLATION; STRESS; BRAIN; BINDS;
D O I
10.1007/s10571-020-00799-1
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Spinal cord injury leads to loss of sensory motor functions below the damaged area, and can significantly affects physical and mental health. An effective spinal cord injury treatment is currently unavailable, in part, because of the intricacy of the brain, as well as the complex pathophysiological mechanism of the injury. Inflammation is an important biological process in multitudinous diseases, with no exception for spinal cord injury. Nuclear factor kappa beta (NF-kappa B) signaling pathway is a key inflammatory element, as it is involved in cell survival, apoptosis, proliferation, differentiation, and immune response. Activation of the NF-kappa B signaling pathway leads to the release of a large number of inflammatory factors that can affect tissue repair. Hence, the inhibition of inflammatory responses could improve the repair of injured spinal cord tissues. Secretory leukocyte protease inhibitor (SLPI) has anti-inflammatory and anti-bacterial properties, and promotes wound healing. SLPI can bind to the promoter region of tumor necrosis factor-alpha and interleukin-8 (IL-8) to inhibit the NF-kappa B signaling pathway. Additionally, SLPI can reduce secondary damages after spinal cord injury, and prevent further complications. In this report, we analyze the pathophysiological mechanism of spinal cord injury, the role of NF-kappa B signaling pathway following spinal cord injury, and how SLPI regulates the NF-kappa B signaling pathway to curtail inflammatory reaction.
引用
收藏
页码:1067 / 1073
页数:7
相关论文
共 69 条
  • [1] Immune dysfunction and chronic inflammation following spinal cord injury
    Allison, D. J.
    Ditor, D. S.
    [J]. SPINAL CORD, 2015, 53 (01) : 14 - 18
  • [2] SLPI Expression on Kidney Biopsies Correlates with Better Clinical Outcomes
    Ambrosi, Nella
    Caro, Fiorella
    Guerrieri, Diego
    Diaz-Alvarez, Leonardo
    Toniolo, Fernanda
    Uva, Pablo
    Incardona, Claudio
    Casadei, Domingo
    Chuluyan, Eduardo
    [J]. TRANSPLANTATION, 2018, 102 : S326 - S327
  • [3] Inflammogenesis of Secondary Spinal Cord Injury
    Anwar, M. Akhtar
    Al Shehabi, Tuqa S.
    Eid, Ali H.
    [J]. FRONTIERS IN CELLULAR NEUROSCIENCE, 2016, 10
  • [4] The Secretory Leukocyte Protease Inhibitor mRNA expression is involved with inflammatory control after downhill exercise in the triceps brachii intermediary head in Wistar rats
    Araujo Minari, Andre Luis
    Oyama, Lila Missae
    Thomatieli dos Santos, Ronaldo Vagner
    [J]. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 2017, 38 (02) : 231 - 239
  • [5] Absence of IL-1β positively affects neurological outcome, lesion development and axonal plasticity after spinal cord injury
    Boato, Francesco
    Rosenberger, Karen
    Nelissen, Sofie
    Geboes, Lies
    Peters, Eva M.
    Nitsch, Robert
    Hendrix, Sven
    [J]. JOURNAL OF NEUROINFLAMMATION, 2013, 10
  • [6] NF-kappa B-Mediated Regulation of Osteoclastogenesis
    Boyce, Brendan F.
    Xiu, Yan
    Li, Jinbo
    Xing, Lianping
    Yao, Zhenqiang
    [J]. ENDOCRINOLOGY AND METABOLISM, 2015, 30 (01) : 35 - 44
  • [7] A secretory leukocyte protease inhibitor variant with improved activity against lung infection
    Camper, N.
    Glasgow, A. M. A.
    Osbourn, M.
    Quinn, D. J.
    Small, D. M.
    McLean, D. T.
    Lundy, F. T.
    Elborn, J. S.
    McNally, P.
    Ingram, R. J.
    Weldon, S.
    Taggart, C. C.
    [J]. MUCOSAL IMMUNOLOGY, 2016, 9 (03) : 669 - 676
  • [8] Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3
    Chen, Shoubo
    Ye, Jingfang
    Chen, Xiangrong
    Shi, Jinnan
    Wu, Wenhua
    Lin, Wenping
    Lin, Weibin
    Li, Yasong
    Fu, Huangde
    Li, Shun
    [J]. JOURNAL OF NEUROINFLAMMATION, 2018, 15
  • [9] Neuroinflammation and M2 microglia: the good, the bad, and the inflamed
    Cherry, Jonathan D.
    Olschowka, John A.
    O'Banion, M. Kerry
    [J]. JOURNAL OF NEUROINFLAMMATION, 2014, 11
  • [10] Chiba Tomoki, 2013, Biomol Concepts, V4, P187, DOI 10.1515/bmc-2012-0039