In highlighting the post-modernity of relative meta-narrative and its paradigm shift, the two major areas of apologetics, namely offensive apologetics and defensive apologetics, are crucial to the maintenance and defense of theology. However, the two main methods of apologetics, namely presupposition and evidence, are traditionally considered to be contradictory to each other, especially after the emergence of rationalism, so apologetics itself shows many limitations. One idea, however, that can provide a consistent basis for presuppositional and evidential apologetics is that God permeates all knowledge. Each method derived from this foundation is also complementary, and this complementarity can be extended to form a unified theory of justification. The principle of unified epistemology in apologetics lies in the universality and normative role of the content of God's revelation. Under the guidance of this principle, the presuppositional and evidential methods of apologetics depend on each other, and create a theoretical basis for the unity of knowledge in Christianity. This article discusses the relationship between the two methods of apologetics and epistemology to prove the scientific, logical and theoretical nature of apologetics. This article also discusses the important role of science in the epistemology of apologetics, that is, the modem scientific method is regarded as the only model of rationality, and science can systematically describe the universal experience of nature to make up for the lack of theology appealing to God's absolute normativity.