Use of pyridoxine and pyridostigmine in children with vincristine-induced neuropathy

被引：15

作者：

Akbayram, Sinan ^{[1
]}

Akgun, Cihangir ^{[1
]}

Dogan, Murat ^{[1
]}

Sayin, Refah ^{[2
]}

Caksen, Huseyin ^{[1
]}

Oner, Ahmet Faik ^{[1
]}

机构：

[1] Yuzuncu Yil Univ, Fac Med, Dept Pediat, TR-65200 Van, Turkey

[2] Yuzuncu Yil Univ, Fac Med, Dept Neurol, TR-65200 Van, Turkey

来源：

INDIAN JOURNAL OF PEDIATRICS | 2010年 / 77卷 / 06期

关键词：

Acute lymphoblastic leukemia (ALL); Vincristine (VCR); Neuropathy; Pyridoxine; Pyridostigmine; PTOSIS;

D O I：

10.1007/s12098-010-0096-z

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Four children with vincristine (VCR)-induced neuropathy are being reported. All cases were followed with the diagnosis of acute lymphoblastic leukemia. Two were boys aged between 2 and 13 year. Electromyographic examination consisted of sensoriomotor polyneuropathy with axonal involvement in three patients. In another patient, it consisted of motor axonal polyneuropathy. In all patients, pyridoxine and pyridostigmine were successfully used in the treatment of VCR-induced neuropathy. They recovered completely with this drug combination. Recovering period of symptoms was between 1-2 week.

引用

页码：681 / 683

页数：3

共 10 条

[1]

BATTLE WM, 1983, YALE J BIOL MED, V56, P277

[2] Vincristine induced cranial polyneuropathy [J].

Ali B. ;

Yilmaz C. ;

Yilmaz N. ;

Oner A.F. .

The Indian Journal of Pediatrics, 2006, 73 (6) :531-533

[3] Vincristine-induced neuropathy as the initial presentation of charcot-Marie-tooth disease in acute lymphoblastic leukemia: A pediatric oncology group study [J].

Chauvenet, AR ;

Shashi, V ;

Selsky, C ;

Morgan, E ;

Kurtzberg, J ;

Bell, B .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2003, 25 (04) :316-320

[4] Vincristine Induced Unilateral Ptosis [J].

Dejan, Skoric ;

Dragana, Bogicevic ;

Ivana, Petronic ;

Borivoje, Babic ;

Marko, Petrovic .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2009, 31 (06) :463-464

[5]

Duman O, 2005, J PEDIAT HEMATOL ONC, V27, P241

[6]

Moudgil SS, 2000, ANN PHARMACOTHER, V34, P1136

[7] Treatment of vincristine-induced bilateral ptosis with pyridoxine and pyridostigmine [J].

Müller, L ;

Kramm, CM ;

Tenenbaum, T ;

Wessalowski, D ;

Göbel, U .

PEDIATRIC BLOOD & CANCER, 2004, 42 (03) :287-288

[8] Pyridoxine and pyridostigmine treatment in vincristine-induced neuropathy [J].

Ozyurek, Hamit ;

Turker, Hande ;

Akbalik, Mehtap ;

Bayrak, Ayse Oytun ;

Ince, Hulya ;

Duru, Feride .

PEDIATRIC HEMATOLOGY AND ONCOLOGY, 2007, 24 (5-8) :447-452

[9] Enhanced vincristine neurotoxicity from drug interactions: Case report and review of literature [J].

Sathiapalan, RK ;

El-Solh, H .

PEDIATRIC HEMATOLOGY AND ONCOLOGY, 2001, 18 (08) :543-546

[10] Brief report - Vincristine neuropathy: Neurophysiological and genetic studies in a case of Wilms tumor [J].

Schiavetti, A ;

Frascarelli, M ;

Uccini, S ;

Novelli, A .

PEDIATRIC BLOOD & CANCER, 2004, 43 (05) :606-609

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