Scale-up of an intermolecular Barbier reaction

被引：6

作者：

Ennis, DS

Lathbury, DC

Wanders, A

Watts, D

机构：

[1] SmithKline Beecham Pharmaceut, Chem Dev, Harlow CM19 5AW, Essex, England

[2] SmithKline Beecham Pharmaceut, Chem Dev, King Of Prussia, PA 19406 USA

[3] SmithKline Beecham Pharmaceut, Chem Dev, Safety Dept, Tonbridge TN11 9AN, Kent, England

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 1998年 / 2卷 / 05期

关键词：

D O I：

10.1021/op980003k

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Addition of n-BuLi to a mixture of ketone (2) and 1,4-diiodobenzene provides access to alcohol (1) in high yield. This procedure has successfully been used on molar scale.

引用

页码：287 / 289

页数：3

共 4 条

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TETRAHEDRON LETTERS, 1993, 34 (13) :2095-2098

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