Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation

被引：141
作者：
Wan, Yichao [1 ,2 ]
Fang, Guoqing [1 ,2 ]
Chen, Hongjuan [1 ,2 ]
Deng, Xu [1 ,2 ]
Tang, Zilong [1 ,2 ]
机构：
[1] Hunan Univ Sci & Technol, Key Lab Theoret Organ Chem & Funct Mol, Minist Educ, Xiangtan 411201, Hunan, Peoples R China
[2] Hunan Univ Sci & Technol, Hunan Prov Key Lab Controllable Preparat & Funct, Hunan Prov Key Lab Adv Mat New Energy Storage & C, Sch Chem & Chem Engn, Xiangtan 411201, Hunan, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2021年 / 226卷
基金：
中国国家自然科学基金;
关键词：
Sulfonamide; Drug design; Anti-Cancer; Structure-activity relationships; NONSTEROIDAL AROMATASE INHIBITORS; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; MCL-1; INHIBITORS; IN-VITRO; HCA IX; PHARMACOLOGICAL EVALUATION; PYRROLIDINE DERIVATIVES; ANTITUMOR-ACTIVITY; DRUG DISCOVERY;
D O I：
10.1016/j.ejmech.2021.113837
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Currently, the arise of drug resistance and undesirable off-target effects of anti-cancer agents are major challenges for cancer treatment, which energizes medicinal chemists to develop more anti-cancer agents with high efficiency and low toxicity continuously. Sulfonamide derivatives are a class of promising compounds with diverse biological activities including anti-cancer, and parts of them have been marketed for cancer therapy, such as Belinostat, ABT-199 and Amsacrine. In this review, we summed up the recent advances of sulfonamide derivatives as potential anti-cancer agents based on the anti-cancer targets, such as aromatase, carbonic anhydrase (CA), anti-apoptotic B-cell lymphoma-2 (Bcl-2) proteins, topoisomerase and phosphatidylinositol 3-kinase (PI3K), and elucidated the corresponding structure-activity relationships (SARs) of most sulfonamide derivatives. We hope this review could provide a clear insight for medicinal chemists in the rational design of more potent and bio-target specific anti-cancer agents. (C) 2021 Elsevier Masson SAS. All rights reserved.
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页数：21
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