The role of lactic acid production by probiotic Lactobacillus species in vaginal health

被引：345

作者：

Tachedjian, Gilda ^{[1
,2
,3
,4
]}

Aldunate, Muriel ^{[1
,2
]}

Bradshaw, Catronia S. ^{[5
,6
]}

Cone, Richard A. ^{[7
]}

机构：

[1] Burnet Inst, Ctr Biomed Res, 85 Commercial Rd, Melbourne, Vic 3004, Australia

[2] Monash Univ, Dept Microbiol, 19 Innovat Walk, Clayton, Vic 3168, Australia

[3] Univ Melbourne, Dept Microbiol & Immunol, Peter Doherty Inst Infect & Immun, 792 Elizabeth St, Melbourne, Vic 3000, Australia

[4] RMIT Univ, Coll Sci Engn & Hlth, Sch Sci, Melbourne, Vic 3000, Australia

[5] Melbourne Sexual Hlth Ctr, 580 Swanston St, Carlton, Vic 3053, Australia

[6] Monash Univ, Cent Clin Sch, Melbourne, Vic 3004, Australia

[7] Johns Hopkins Univ, Dept Biophys, 3400 North Charles St, Baltimore, MD USA

来源：

RESEARCH IN MICROBIOLOGY | 2017年 / 168卷 / 9-10期

基金：

英国医学研究理事会;

关键词：

Microbiota; Lactobacilli; Probiotics; Lactic acid; Metabolites; Vagina; SEXUALLY-TRANSMITTED INFECTIONS; VAGINOSIS-ASSOCIATED BACTERIA; INNATE IMMUNE-RESPONSE; SIMPLEX-VIRUS TYPE-2; DOUBLE-BLIND; RHAMNOSUS GR-1; REUTERI RC-14; IN-VITRO; MATRIX METALLOPROTEINASE-8; GARDNERELLA-VAGINALIS;

D O I：

10.1016/j.resmic.2017.04.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Vaginal eubiosis is characterised by beneficial lactobacillus-dominated microbiota. In contrast, vaginal dysbiosis (e.g. bacterial vaginosis, BV), characterised by an overgrowth of multiple anaerobes, is associated with an increased risk of adverse urogenital and reproductive health outcomes. A major distinguishing feature between the vaginal environment in states of eubiosis and dysbiosis is a high concentration of lactic acid, produced by lactobacilli, that acidifies the vagina in eubiosis versus a sharp drop in lactic acid and an increase in pH in dysbiosis. Here we review the antimicrobial, antiviral and immunomodulatory properties of lactic acid and the use of lactic acid and lactobacilli probiotics in preventing or treating BV. (C) 2017 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur.

引用

页码：782 / 792

页数：11

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