Systematic Review and Meta-Analysis of the Significance of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Isolates

被引：134

作者：

van Hal, Sebastiaan J. ^{[1
]}

Paterson, David L. ^{[2
]}

机构：

[1] Liverpool Hosp, Dept Microbiol & Infect Dis, Sydney, NSW 1087, Australia

[2] Univ Queensland, Clin Res Ctr, Herston, Qld 4029, Australia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 01期

关键词：

BLOOD-STREAM INFECTIONS; REDUCED SUSCEPTIBILITY; CLINICAL-FEATURES; INHIBITORY CONCENTRATION; NATIONWIDE SURVEILLANCE; JAPANESE HOSPITALS; SERIOUS INFECTIONS; TREATMENT OUTCOMES; MEDICAL-CENTER; RESISTANT;

D O I：

10.1128/AAC.01133-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The prevalence of heteroresistant vancomycin-intermediate Staphylococcus aureus (hVISA) is 1.3% in published studies. Clinical associations include high-inoculum infections and glycopeptide failure, with hVISA infections associated with a 2.37-times-greater failure rate (95% confidence interval [CI], 1.53 to 3.67) compared to vancomycin-sensitive Staphylococcus aureus (VSSA) infections. Despite this, 30-day mortality rates were similar to those for VSSA infections (odds ratio [OR], 1.18; 95% CI, 0.81 to 1.74). The optimal therapy for hVISA requires further study.

引用

页码：405 / 410

页数：6

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