Riluzole delayed appearance of parkinsonian motor abnormalities in a chronic MPTP monkey model

被引：41
作者：
Bezard, E
Stutzmann, JM
Imbert, C
Boraud, T
Boireau, A
Gross, CE
机构：
[1] Univ Bordeaux 2, Neurophysiol Lab, CNRS, UMR 5543,Basal Gang, F-33076 Bordeaux, France
[2] Rhone Poulenc Rorer, Ctr Rech Vitry Alfortville, CNS Programme, F-94403 Vitry Sur Seine, France
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1998年 / 356卷 / 2-3期
关键词：
riluzole; neuroprotection; MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine); monkey; Parkinson's disease;
D O I：
10.1016/S0014-2999(98)00537-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Preliminary studies have shown that riluzole, a Na+ channel blocker with antiglutamatergic activity, has neuroprotective efficacy in several models of acute dopaminergic neurodegeneration. A chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkey model which comes closer to the slow evolution of Parkinson's disease has recently been developed in order to allow dynamic studies. The present results show that riluzole delayed the appearance of parkinsonian motor abnormalities in this dynamic model, using from 10.2 +/- 1.6 daily injections for the MPTP-treated monkeys (n = 4) to 16.5 +/- 2.0 daily injections for the MPTP + riluzole-treated monkeys (n = 4). These results strongly suggest that riluzole may be beneficial to slow down the rate of progression of Parkinson's disease. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：101 / 104
页数：4
相关论文
共 23 条
[1]   Neuroprotective effects of riluzole on a model of Parkinson's disease in the rat [J].
Barneoud, P ;
Mazadier, M ;
Miquet, JM ;
Parmentier, S ;
Dubedat, P ;
Doble, A ;
Boireau, A .
NEUROSCIENCE, 1996, 74 (04) :971-983
[2]   RILUZOLE PREVENTS MPTP-INDUCED PARKINSONISM IN THE RHESUS-MONKEY - A PILOT-STUDY [J].
BENAZZOUZ, A ;
BORAUD, T ;
DUBEDAT, P ;
BOIREAU, A ;
STUTZMANN, JM ;
GROSS, C .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 284 (03) :299-307
[3]   Compensatory mechanisms in experimental and human parkinsonism: Towards a dynamic approach [J].
Bezard, E ;
Gross, CE .
PROGRESS IN NEUROBIOLOGY, 1998, 55 (02) :93-116
[4]   Compensatory effects of glutamatergic inputs to the substantia nigra pars compacta in experimental Parkinsonism [J].
Bezard, E ;
Boraud, T ;
Bioulac, B ;
Gross, CE .
NEUROSCIENCE, 1997, 81 (02) :399-404
[5]   A chronic MPTP model reproducing the slow evolution of Parkinson's disease: evolution of motor symptoms in the monkey [J].
Bezard, E ;
Imbert, C ;
Deloire, X ;
Bioulac, B ;
Gross, CE .
BRAIN RESEARCH, 1997, 766 (1-2) :107-112
[6]   Kinetics of nigral degeneration in a chronic model of MPTP-treated mice [J].
Bezard, E ;
Dovero, S ;
Bioulac, B ;
Gross, CE .
NEUROSCIENCE LETTERS, 1997, 234 (01) :47-50
[7]   Presymptomatic revelation of experimental Parkinsonism [J].
Bezard, E ;
Boraud, T ;
Bioulac, B ;
Gross, CE .
NEUROREPORT, 1997, 8 (02) :435-438
[8]  
BEZARD E, 1998, IN PRESS REV NEUROSC, V9
[9]  
BIRKMAYER W, 1961, Wien Klin Wochenschr, V73, P787
[10]   RILUZOLE AND EXPERIMENTAL PARKINSONISM - PARTIAL ANTAGONISM OF MPP(+)-INDUCED INCREASE IN STRIATAL EXTRACELLULAR DOPAMINE IN RATS IN-VIVO [J].
BOIREAU, A ;
MIQUET, JM ;
DUBEDAT, P ;
MEUNIER, M ;
DOBLE, A .
NEUROREPORT, 1994, 5 (16) :2157-2160
123