Outcomes of intensity-modulated radiotherapy versus conventional radiotherapy for hypopharyngeal cancer

被引：28

作者：

Mok, Gary ^{[1
,5
]}

Gauthier, Isabelle ^{[1
,5
]}

Jiang, Haiyan ^{[2
]}

Huang, Shao Hui ^{[1
,5
]}

Chan, Kelvin ^{[3
,7
]}

Witterick, Ian J. ^{[4
,6
]}

O'Sullivan, Brian ^{[1
,5
,6
]}

Waldron, John N. ^{[1
,5
,6
]}

Bayley, Andrew J. ^{[1
,5
]}

Cho, B. C. John ^{[1
,5
]}

Cummings, Bernard J. ^{[1
,5
]}

Dawson, Laura A. ^{[1
,5
]}

Hope, Andrew J. ^{[1
,5
]}

Kim, John J. ^{[1
,5
]}

Ringash, Jolie ^{[1
,5
]}

机构：

[1] Princess Margaret Canc Ctr, Radiat Med Program, Toronto, ON M5G 2M9, Canada

[2] Princess Margaret Canc Ctr, Dept Biostat, Toronto, ON M5G 2M9, Canada

[3] Princess Margaret Canc Ctr, Div Med Oncol, Toronto, ON M5G 2M9, Canada

[4] Mt Sinai Hosp, Dept Otolaryngol, Toronto, ON M5G 1X5, Canada

[5] Univ Toronto, Dept Radiat Oncol, Toronto, ON, Canada

[6] Univ Toronto, Dept Otolaryngol Head & Neck Surg, Toronto, ON, Canada

[7] Univ Toronto, Dept Med, Toronto, ON, Canada

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2015年 / 37卷 / 05期

关键词：

hypopharynx; intensity-modulated radiotherapy (IMRT); 3D conformal radiotherapy; larynx preservation; SQUAMOUS-CELL CARCINOMA; CONCURRENT CHEMOTHERAPY; INDUCTION CHEMOTHERAPY; ADVANCED LARYNGEAL; ADVANCED HEAD; OROPHARYNGEAL; PRESERVATION; P16;

D O I：

10.1002/hed.23649

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

BackgroundThe purpose of this study was to discuss if the adoption of intensity-modulated radiotherapy (IMRT) for hypopharyngeal squamous cell carcinoma (SCC) has improved the outcome. MethodsWe compared 3-dimensional (3D) radiotherapy (RT) and IMRT in all patients with hypopharyngeal SCC treated with curative intent RT or chemoradiation therapy (CRT) from January 1, 2000, to February 28, 2010. Locoregional control, overall survival (OS), distant relapse rate, larynx preservation rate, and enteral feeding tube duration were analyzed. ResultsOf 181 consecutive patients, 90 received 3D-RT and 91 received IMRT. At 3 years, the IMRT group had higher locoregional control compared with the 3D-RT group (75% vs 58%; p = .003), but similar OS (50% vs 52%; p = .99), distant relapse rate (23% vs 20%; p = .79), and larynx-preservation rate (90% vs 86%; p = .16). The 2-year enteral feeding tube dependency rate was similar in both groups (19% vs 18%; p = .12). ConclusionPatients with hypopharyngeal SCC treated with IMRT showed a higher locoregional control compared with 3D-RT. However, distant-relapse rate and OS remain comparable between treatment techniques. (c) 2014 Wiley Periodicals, Inc. Head Neck37: 655-661, 2015

引用

页码：655 / 661

页数：7

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