Exploring the Impact of Single-Nucleotide Polymorphisms on Translation

被引：133

作者：

Robert, Francis ^{[1
]}

Pelletier, Jerry ^{[1
,2
,3
]}

机构：

[1] McGill Univ, Dept Biochem, Montreal, PQ, Canada

[2] McGill Univ, Dept Oncol, Montreal, PQ, Canada

[3] McGill Univ, Rosalind & Morris Goodman Canc Res Ctr, Montreal, PQ, Canada

来源：

FRONTIERS IN GENETICS | 2018年 / 9卷

基金：

加拿大健康研究院;

关键词：

translation initiation; eIF4F; ribosome recruitment; SNP; genetic variant; INTERNAL RIBOSOME ENTRY; OPEN READING FRAMES; 5' NONCODING REGION; MESSENGER-RNA; UNTRANSLATED REGIONS; PROTEIN EXPRESSION; GENETIC-VARIATION; BREAST-CANCER; BINDING; MUTATIONS;

D O I：

10.3389/fgene.2018.00507

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Over the past 15 years, sequencing of the human genome and The Cancer Genome Atlas (TCGA) project have led to comprehensive lists of single-nucleotide polymorphisms (SNPs) and gene mutations across a large number of human samples. However, our ability to predict the functional impact of SNPs and mutations on gene expression is still in its infancy. Here, we provide key examples to help understand how mutations present in genes can affect translational output.

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页数：11

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