High tetanus antitoxin antibody concentrations in the Netherlands: A seroepidemiological study

被引：24

作者：

Steens, Anneke ^{[1
]}

Mollema, L. ^{[1
]}

Berbers, G. A. M. ^{[2
]}

van Gageldonk, P. G. M. ^{[2
]}

van der Klis, F. R. ^{[2
]}

de Melker, H. E. ^{[1
]}

机构：

[1] Natl Inst Publ Hlth & Environm, Ctr Infect Dis Control, Epidemiol & Surveillance Unit, NL-3720 BA Bilthoven, Netherlands

[2] Natl Inst Publ Hlth & Environm, Ctr Infect Dis Control, Lab Infect Dis & Screening, NL-3720 BA Bilthoven, Netherlands

来源：

VACCINE | 2010年 / 28卷 / 49期

关键词：

Tetanus antitoxin antibodies; Tetanus vaccination; Post-exposure prophylaxis guidelines; PROPHYLAXIS; DIPHTHERIA; OUTBREAK;

D O I：

10.1016/j.vaccine.2010.09.036

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We assessed the level and determinants of tetanus-antitoxin (TT)-antibodies in the Dutch population. Additionally, we evaluated the national guidelines for post-exposure prophylaxis. Serum samples and questionnaire data from a cross-sectional, population-based study were obtained from 7903 individuals. Serum antitoxin antibodies were assessed with a multiplex immunoassay. Multivariable linear regression was used to explore factors associated with antibody concentration. The overall seroprevalence was 94% with a geometric mean concentration (GMC) of 0.91 IU/ml. The TT-GMC increased with age in the age-cohorts of 13-23 years, which coincides with the meningococcal C conjugate mass-vaccination in 2002. Lower seroprevalences were found in individuals born before introduction of routine vaccination, first-generation migrants from non-Western countries born before 1984, and conservative Protestants living in the Dutch 'Bible belt'. Only 10% of those eligible for post-exposure prophylaxis were not sufficiently protected against tetanus. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：7803 / 7809

页数：7

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