A practical synthetic approach to chiral α-aryl substituted ethylphosphonates

被引：78
作者：
Goulioukina, NS
Dolgina, TM
Beletskaya, IP
Henry, JC
Lavergne, D
Ratovelomanana-Vidal, V
Genet, JP
机构：
[1] Moscow State Univ, Dept Chem, Moscow 119899, Russia
[2] Ecole Natl Super Chim, UMR CNRS 7573, Lab Synth Select Organ & Prod Nat, F-75231 Paris 05, France
来源：
TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
D O I：
10.1016/S0957-4166(01)00031-3
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A convenient general method is reported for the synthesis of alpha -aryl substituted ethylphosphonic acids and esters by hydrogenation of alpha -aryl substituted ethenylphosphonic acids and esters. Racemic alpha -arylethylphosphonic acids and esters were prepared in 70-88%, yield under palladium-assisted transfer hydrogenation conditions using ammonium formate. Asymmetric hydrogenation of alpha -arylethenylphosphonic acids using chiral Ru(II) catalysts led to alpha -arylethylphosphonic acids with enantiomeric excesses up to 86%. (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码：319 / 327
页数：9
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