Dynamic kinetic resolution allows a highly enantioselective synthesis of cis-α-aminocycloalkanols by ruthenium-catalyzed asymmetric hydrogenation

被引：58

作者：

Liu, Sheng

Xie, Jian-Hua

Wang, Li-Xin

Zhou, Qi-Lin ^{[1
]}

机构：

[1] Nankai Univ, State Key Lab, Tianjin 300071, Peoples R China

[2] Nankai Univ, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 39期

关键词：

amino alcohols; asymmetric catalysis; diamines; hydrogenation; ruthenium; EFFICIENT SYNTHESIS; ORGANIC-SYNTHESIS; METAL-COMPLEXES; DERIVATIVES; KETONES; ALCOHOLS; LIGANDS;

D O I：

10.1002/anie.200702491

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Resolutely dynamic hydrogenation: A highly efficient asymmetric hydrogenation of racemic N,N-disubstituted α-aminocycloalkanones involving dynamic kinetic resolution in the presence of a ruthenium catalyst gives chiral α-aminocycloalkanols with excellent enantioselectivities and cis diastereoselectivities (see scheme). A synthesis of optically pure U-(-)-50488 based on this reaction is reported. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7506 / 7508

页数：3

共 39 条

[1] 1,2-amino alcohols and their heterocyclic derivatives as chiral auxiliaries in asymmetric synthesis [J].