Microwave-assisted iridium-catalyzed [2+2+2] cycloaddition of resin-bound dipropargylamine with alkynes

被引：21
作者：
Shanmugasundaram, Muthian [1 ]
Aguirre, Ana Luisa [1 ]
Leyva, Melissa [1 ]
Quan, Belli [1 ]
Martinez, Luis E. [1 ]
机构：
[1] Univ Texas, Dept Chem, El Paso, TX 79968 USA
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 43期
基金：
美国国家卫生研究院;
关键词：
solid-phase synthesis; microwave; cycloaddition; isoindolines;
D O I：
10.1016/j.tetlet.2007.08.073
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The [Ir(COD)Cl](2)/dppe system effectively catalyzes the solid-phase [2+2+2] cycloaddition of resin-bound dipropargylamine with alkynes under microwave conditions. The reaction results in high purity of isoindoline derivatives with moderate yields. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7698 / 7701
页数：4
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