SYNTHESIS, ANTITUMOR, AND ANTI-MONOAMINE OXIDASE PROPERTIES OF 2,4,4-TRISUBSTITUTED TRIAZOLOBENZO[h]QUINAZOLINES

被引：4

作者：

Markosyan, A. I. ^{[1
]}

Dilanyan, S. V. ^{[1
]}

Arsenyan, F. G. ^{[1
]}

Sukasyan, R. S. ^{[1
]}

Sarkisyan, I. S. ^{[1
]}

Garibdzhanyan, B. T.

机构：

[1] Natl Acad Sci Republ Armenia, Inst Fine Organ Chem Sci & Technol, Ctr Organ & Pharmaceut Chem, Yerevan, Armenia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2010年 / 44卷 / 03期

关键词：

Benzo[h]quinazoline; cyclization; antitumor and anti-monoamine oxidase activity; THYMIDYLATE SYNTHASE; DERIVATIVES;

D O I：

10.1007/s11094-010-0409-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The interaction of 1-amino-3-methyl-3-ethyl-3,4-dihydronaphthaline-2-carbonitrile (I) with propanoic acid chloranhyride was used to synthesize the corresponding amidonitrile II, which was then cyclized to form 2,5-diethyl-5-methyl-4-oxo-5,6-dihydrobenzo[h] quinazolin-4(3H)-one (III). Interaction of aminonitrile I with triethylorthoformate and carboxylic acid hydrazides yielded 2-substituted 4-methyl-4-ethyl-4,5-dihydrobenzo[ h][1,2,4] triazolo[1,5-c] quinazolines (IV-XVIII). The antitumor and anti-monoamine oxidase properties of the compounds obtained were studied.

引用

页码：111 / 114

页数：4

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