Constituents of Croton megalocarpus with Potential Anti-HIV Activity

被引：12

作者：

Terefe, Ermias Mergia ^{[1
,2
]}

Okalebo, Faith A. ^{[2
]}

Derese, Solomon ^{[3
]}

Muriuki, Joseph ^{[4
]}

Rotich, Winnie ^{[5
]}

Mas-Claret, Eduard ^{[6
]}

Sadgrove, Nicholas ^{[6
]}

Padilla-Gonzalez, Guillermo F. ^{[6
]}

Prescott, Thomas A. K. ^{[6
]}

Siddique, Holly ^{[6
]}

Langat, Moses K. ^{[6
]}

机构：

[1] US Int Univ Africa, Sch Pharm & Hlth Sci, Dept Pharmacol & Pharmacognosy, Nairobi 1463400800, Kenya

[2] Univ Nairobi, Dept Pharmacol & Pharmacognosy, Coll Hlth Sci, Nairobi 1463400800, Kenya

[3] Univ Nairobi, Dept Chem, Nairobi 3019700100, Kenya

[4] Kenya Govt Med Res Ctr, Ctr Virus Res, Nairobi 5462800200, Kenya

[5] Sigowet Soin Sub Cty Hosp, Kericho 11220200, Kenya

[6] Royal Bot Gardens, Kew, Richmond TW9 3AE, Surrey, England

来源：

JOURNAL OF NATURAL PRODUCTS | 2022年

关键词：

CROTOFOLANE-TYPE DITERPENOIDS; REVERSE-TRANSCRIPTASE; NATURAL-PRODUCTS; LEAVES; ROOTS; ASSAY; AIDS;

D O I：

10.1021/acs.jnatprod.1c01013

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Reported herein is an anti-HIV monochlorinated compound, 1 beta-acetoxy-3 beta-chloro-5 alpha,6 alpha-dihydroxycrotocascarin L (1), of the rare crotofolane diterpenoid class. Compound 1, a suspected artifact of extraction, along with the previously undescribed 11 beta-acetoxycrotocascarin L (2) and a known compound, crotocascarin K (3), were isolated from the bark of Croton megalocarpus, a Kenyan oil-producing seed crop. Compounds 1 and 3 inhibited HIV-1 replication with IC50 values of 28 and 5.5 nM, respectively. Furthermore, both compounds lacked cytotoxicity toward MT-4 cells and FM-55-M1 cells at concentrations of up to 50 mu M. Compounds 1 and 3 were both found to inhibit HIV-1 protease.

引用

页码：1861 / 1866

页数：6

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