For numerous high-energy physics applications superconducting cables are subjected to large stresses and high magnetic fields during service. It is essential to know how cables perform in these operating conditions. Transverse loading experiments on wire has shown that a significant drop in critical current occurs for stresses greater than 50 MPa. However, many applications require that the Bi-2212 conductor withstand stresses greater than 100 MPa without permanent degradation. Therefore, a study of epoxy impregnated cables, identical to those used in accelerator magnet applications, has been performed. This work presents the first results of Rutherford cables of Bi-2212 with transverse stress. The results show that the cable can withstand stresses up to 60 MPa with a strain of about 0.3 % for the face loading orientation and 100 MPa for the edge loading orientation.