The HIV-1 envelope glycoproteins: Fusogens, antigens, and immunogens

被引：1293
作者：
Wyatt, R
Sodroski, J [1 ]
机构：
[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol AIDS,Dept Pathol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
来源：
SCIENCE | 1998年 / 280卷 / 5371期
关键词：
D O I：
10.1126/science.280.5371.1884
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The human immunodeficiency virus-type 1 (HIV-1) envelope glycoproteins interact with receptors on the target cell and mediate virus entry by fusing the viral and cell membranes. The structure of the envelope glycoproteins has evolved to fulfill these functions while evading the neutralizing antibody response. An understanding of the viral strategies for immune evasion should guide attempts to improve the immunogenicity of the HIV-1envelope glycoproteins and, ultimately, aid in HIV-1vaccine development.
引用
收藏
页码：1884 / 1888
页数：5
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共 176 条
[51]   Immunopathogenic mechanisms of HIV infection [J].
Fauci, AS ;
Pantaleo, G ;
Stanley, S ;
Weissman, D .
ANNALS OF INTERNAL MEDICINE, 1996, 124 (07) :654-663
[52]   A SYNCYTIA ASSAY FOR HUMAN IMMUNODEFICIENCY VIRUS TYPE-I (HIV-I) ENVELOPE PROTEIN AND ITS USE IN STUDYING HIV-I MUTATIONS [J].
FELSER, JM ;
KLIMKAIT, T ;
SILVER, J .
VIROLOGY, 1989, 170 (02) :566-570
[53]   HIV-1 Entry Cofactor: Functional cDNA Cloing of a Seven-Transmembrane, G protein-Coupled Receptor [J].
Feng, Yu ;
Broder, Christopher C. ;
Kennedy, Paul E. ;
Berger, Edward A. .
JOURNAL OF IMMUNOLOGY, 2011, 186 (11) :872-877
[54]   Host-derived ICAM-1 glycoproteins incorporated on human immunodeficiency virus type 1 are biologically active and enhance viral infectivity [J].
Fortin, JF ;
Cantin, R ;
Lamontagne, G ;
Tremblay, M .
JOURNAL OF VIROLOGY, 1997, 71 (05) :3588-3596
[55]   T cells expressing activated LFA-1 are more susceptible to infection with human immunodeficiency virus type 1 particles bearing host-encoded ICAM-1 [J].
Fortin, JF ;
Cantin, R ;
Tremblay, MJ .
JOURNAL OF VIROLOGY, 1998, 72 (03) :2105-2112
[56]   Neutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex [J].
Fouts, TR ;
Binley, JM ;
Trkola, A ;
Robinson, JE ;
Moore, JP .
JOURNAL OF VIROLOGY, 1997, 71 (04) :2779-2785
[57]   Acquisition of host cell-surface-derived molecules by HIV-1 [J].
Frank, I ;
Stoiber, H ;
Godar, S ;
Stockinger, H ;
Steindl, F ;
Katinger, HWD ;
Dierich, MP .
AIDS, 1996, 10 (14) :1611-1620
[58]   CHARACTERIZATION OF THE FUSION DOMAIN OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE GLYCOPROTEIN GP41 [J].
FREED, EO ;
MYERS, DJ ;
RISSER, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (12) :4650-4654
[59]   IDENTIFICATION OF THE PRINCIPAL NEUTRALIZING DETERMINANT OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 AS A FUSION DOMAIN [J].
FREED, EO ;
MYERS, DJ ;
RISSER, R .
JOURNAL OF VIROLOGY, 1991, 65 (01) :190-194
[60]   IDENTIFICATION AND CHARACTERIZATION OF A NEUTRALIZATION SITE WITHIN THE 2ND VARIABLE REGION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GP120 [J].
FUNG, MSC ;
SUN, CRY ;
GORDON, WL ;
LIOU, RS ;
CHANG, TW ;
SUN, WNC ;
DAAR, ES ;
HO, DD .
JOURNAL OF VIROLOGY, 1992, 66 (02) :848-856
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