Human muscle in gene edited pigs for treatment of volumetric muscle loss

被引：5
|
作者：
Greising, Sarah M. [1 ]
Weiner, Joshua I. [2 ]
Garry, Daniel J. [3 ,4 ,5 ,6 ]
Sachs, David H. [2 ,7 ]
Garry, Mary G. [3 ,4 ,5 ,6 ]
机构：
[1] Univ Minnesota, Sch Kinesiol, Minneapolis, MN 55455 USA
[2] Columbia Univ, Coll Phys & Surg, Columbia Ctr Translat Immunol, Dept Surg, New York, NY USA
[3] Univ Minnesota, Dept Med, Cardiovasc Div, Minneapolis, MN 55455 USA
[4] Univ Minnesota, Stem Cell Inst, Minneapolis, MN 55455 USA
[5] Univ Minnesota, Lillehei Heart Inst, Minneapolis, MN 55455 USA
[6] NorthStar Genom, Eagan, MN 55122 USA
[7] Massachusetts Gen Hosp, Dept Surg, Boston, MA USA
来源：
FRONTIERS IN GENETICS | 2022年 / 13卷
关键词：
xenotransplantation; skeletal muscle function; human animal chimeras; somatic cell nuclear transfer; blastocyst complementation; OPERATION IRAQI FREEDOM; LOSS INJURY; EPIDEMIOLOGY; WOUNDS; TOLERANCE; SCAFFOLDS; PANCREAS; REPAIR; MOUSE; CELL;
D O I：
10.3389/fgene.2022.948496
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Focusing on complex extremity trauma and volumetric muscle loss (VML) injuries, this review highlights: 1) the current pathophysiologic limitations of the injury sequela; 2) the gene editing strategy of the pig as a model that provides a novel treatment approach; 3) the notion that human skeletal muscle derived from gene edited, humanized pigs provides a groundbreaking treatment option; and 4) the impact of this technologic platform and how it will advance to far more multifaceted applications. This review seeks to shed insights on a novel treatment option using gene edited pigs as a platform which is necessary to overcome the clinical challenges and limitations in the field.
引用
收藏
页数：6
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