Mitochondrial oversight of cellular Ca2+ signaling

被引:176
作者
Babcock, DF [1 ]
Hille, B [1 ]
机构
[1] Univ Washington, Sch Med, Dept Physiol & Biophys, Seattle, WA 98195 USA
关键词
D O I
10.1016/S0959-4388(98)80067-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Mitochondria, the metabolic powerhouses of the cell, can sequester and release large amounts of Ca2+. This import and export of Ca2+ helps to adjust energy production to cellular needs. Recent advances show that mitochondrial Ca2+ fluxes play a major role in normal Ca2+ signaling.
引用
收藏
页码:398 / 404
页数:7
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共 62 条
  • [1] GLUTAMATE-INDUCED NEURONAL DEATH - A SUCCESSION OF NECROSIS OR APOPTOSIS DEPENDING ON MITOCHONDRIAL-FUNCTION
    ANKARCRONA, M
    DYPBUKT, JM
    BONFOCO, E
    ZHIVOTOVSKY, B
    ORRENIUS, S
    LIPTON, SA
    NICOTERA, P
    [J]. NEURON, 1995, 15 (04) : 961 - 973
  • [2] Inhibition of Bax channel-forming activity by Bcl-2
    Antonsson, B
    Conti, F
    Ciavatta, A
    Montessuit, S
    Lewis, S
    Martinou, I
    Bernasconi, L
    Bernard, A
    Mermod, JJ
    Mazzei, G
    Maundrell, K
    Gambale, F
    Sadoul, R
    Martinou, JC
    [J]. SCIENCE, 1997, 277 (5324) : 370 - 372
  • [3] Mitochondrial participation in the intracellular Ca2+ network
    Babcock, DF
    Herrington, J
    Goodwin, PC
    Park, YB
    Hille, B
    [J]. JOURNAL OF CELL BIOLOGY, 1997, 136 (04) : 833 - 844
  • [4] CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons
    Baron, KT
    Thayer, SA
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 340 (2-3) : 295 - 300
  • [5] Mitochondria, free radicals, and neurodegeneration
    Beal, MF
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 1996, 6 (05) : 661 - 666
  • [6] Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore
    Beutner, G
    Ruck, A
    Riede, B
    Welte, W
    Brdiczka, D
    [J]. FEBS LETTERS, 1996, 396 (2-3) : 189 - 195
  • [7] Intracellular Ca2+ increases the mitochondrial NADH concentration during elevated work in intact cardiac muscle
    Brandes, R
    Bers, DM
    [J]. CIRCULATION RESEARCH, 1997, 80 (01) : 82 - 87
  • [8] A reevaluation of the role of mitochondria in neuronal Ca2+ homeostasis
    Budd, SL
    Nicholls, DG
    [J]. JOURNAL OF NEUROCHEMISTRY, 1996, 66 (01) : 403 - 411
  • [9] CALCIUM CYCLE OF MITOCHONDRIA
    CARAFOLI, E
    [J]. FEBS LETTERS, 1979, 104 (01): : 1 - 5
  • [10] MODULATION OF INTRAMITOCHONDRIAL FREE CA2+ CONCENTRATION BY ANTAGONISTS OF NA+-CA2+ EXCHANGE
    COX, DA
    MATLIB, MA
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1993, 14 (11) : 408 - 413