NMR chemical shift assignments of RNA oligonucleotides to expand the RNA chemical shift database

被引：5

作者：

Liu, Yaping ^{[1
]}

Kotar, Anita ^{[1
,5
]}

Hodges, Tracy L. ^{[1
]}

Abdallah, Kyrillos ^{[1
]}

Taleb, Mallak H. ^{[1
]}

Bitterman, Brayden A. ^{[1
]}

Jaime, Sara ^{[1
]}

Schaubroeck, Kyle J. ^{[1
]}

Mathew, Ethan ^{[1
]}

Morgenstern, Nicholas W. ^{[1
]}

Lohmeier, Anthony ^{[1
]}

Page, Jordan L. ^{[1
]}

Ratanapanichkich, Matt ^{[1
]}

Arhin, Grace ^{[1
]}

Johnson, Breanna L. ^{[1
]}

Cherepanov, Stanislav ^{[1
]}

Moss, Stephen C. ^{[1
]}

Zuniga, Gisselle ^{[1
]}

Tilson, Nicholas J. ^{[1
]}

Yeoh, Zoe C. ^{[2
]}

Johnson, Bruce A. ^{[3
]}

Keane, Sarah C. ^{[1
,4
]}

机构：

[1] Univ Michigan, Biophys Program, 930 N Univ Ave, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Biol Chem, 1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA

[3] CUNY Adv Sci Res Ctr, Struct Biol Initiat, 85 St Nicholas Terrace, New York, NY 10031 USA

[4] Univ Michigan, Dept Chem, 930 N Univ Ave, Ann Arbor, MI 48109 USA

[5] Natl Inst Chem, Slovenian NMR Ctr, Hajdrihova 19, Ljubljana 1000, Slovenia

来源：

BIOMOLECULAR NMR ASSIGNMENTS | 2021年 / 15卷 / 02期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

RNA; Solution NMR spectroscopy; GAGA tetraloop; Chemical shift database; SECONDARY STRUCTURE; PREDICTION; C-13; PROTON; MISMATCHES; H-1; NUCLEOSIDES; DEPENDENCE; HYDROGEN;

D O I：

10.1007/s12104-021-10049-0

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

RNAs play myriad functional and regulatory roles in the cell. Despite their significance, three-dimensional structure elucidation of RNA molecules lags significantly behind that of proteins. NMR-based studies are often rate-limited by the assignment of chemical shifts. Automation of the chemical shift assignment process can greatly facilitate structural studies, however, accurate chemical shift predictions rely on a robust and complete chemical shift database for training. We searched the Biological Magnetic Resonance Data Bank (BMRB) to identify sequences that had no (or limited) chemical shift information. Here, we report the chemical shift assignments for 12 RNA hairpins designed specifically to help populate the BMRB.

引用

页码：479 / 490

页数：12

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