Mycobacterium africanum-Review of an Important Cause of Human Tuberculosis in West Africa

被引：179
作者：
de Jong, Bouke C. [1 ,2 ,3 ]
Antonio, Martin [1 ]
Gagneux, Sebastien [4 ,5 ]
机构：
[1] Bacterial Dis Programme, MRC Labs, Fajara, Gambia
[2] NYU, Div Infect Dis, New York, NY USA
[3] Inst Trop Med, Mycobacteriol Unit, B-2000 Antwerp, Belgium
[4] MRC Natl Inst Med Res, London, England
[5] Swiss Trop & Publ Hlth Inst, Basel, Switzerland
来源：
PLOS NEGLECTED TROPICAL DISEASES | 2010年 / 4卷 / 09期
基金：
美国国家卫生研究院; 英国医学研究理事会;
关键词：
PULMONARY TUBERCULOSIS; GENETIC DIVERSITY; MOLECULAR EPIDEMIOLOGY; GENOMIC DELETIONS; TUBERCLE-BACILLI; COMPLEX STRAINS; DRUG-RESISTANCE; THIACETAZONE; PHYLOGENY; EVOLUTION;
D O I：
10.1371/journal.pntd.0000744
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Mycobacterium africanum consists of two phylogenetically distinct lineages within the Mycobacterium tuberculosis complex, known as M. africanum West African 1 and M. africanum West African 2. These lineages are restricted to West Africa, where they cause up to half of human pulmonary tuberculosis. In this review we discuss the definition of M. africanum, describe the prevalence and restricted geographical distribution of M. africanum West African 1 and 2, review the occurrence of M. africanum in animals, and summarize the phenotypic differences described thus far between M. africanum and M. tuberculosis sensu stricto.
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页数：9
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