Improvement of obesity and glucose tolerance by acetate in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats

被引：257

作者：

Yamashita, Hiromi ^{[1
]}

Fujisawa, Katsuhiko ^{[1
]}

Ito, Erina ^{[1
]}

Idei, Seika ^{[1
]}

Kawaguchi, Nobuyo ^{[1
]}

Kimoto, Masumi ^{[1
]}

Hiemori, Miki ^{[1
]}

Tsuji, Hideaki ^{[1
]}

机构：

[1] Okayama Prefectural Univ, Fac Hlth & Welf Sci, Dept Nutrit Sci, Soja, Okayama 7191197, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2007年 / 71卷 / 05期

关键词：

acetate; lipid metabolism; obesity; Otsuka Long-Evans Tokushima Fatty (OLETF); rats; glucose tolerance;

D O I：

10.1271/bbb.60668

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acetate has been found to have an inhibitory effect on the activity of carbohydrate-responsive element-binding protein (ChREBP) in cultured hepatocytes, this being a transcription factor that regulates several genes required for the conversion of glucose to fatty acids in the liver. The aim of this study was to investigate whether an oral administration of acetate would contribute to reducing lypogenic genes and protecting against obesity. We orally injected 5.2mg/kg BW of acetate to obesity-linked type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. The treatment with acetate showed a marked reduction in lipid accumulation in the adipose tissue, protection against accumulation of fat in the liver, and improved glucose tolerance. An analysis by Northern blotting revealed that the transcripts of several lipogenic genes in the liver of OLETF rats were decreased by the acetate treatment. On the basis of those results, it was indicated that acetate was a potential compound to improve obesity and obesity-linked type 2 diabetes.

引用

页码：1236 / 1243

页数：8

共 30 条

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