Kalshinoids A-F, Anti-inflammatory Sesquiterpenes from Kalimeris shimadae

被引：23

作者：

Wang, Guo-Kai ^{[1
,2
]}

Zhang, Nan ^{[1
]}

Yao, Jian-Neng ^{[3
]}

Yu, Yang ^{[3
]}

Wang, Gang ^{[1
]}

Hung, Chin-Chuan ^{[4
]}

Cheng, Yung-Yi ^{[2
,5
]}

Morris-Natschke, Susan L. ^{[2
]}

Zhou, Zhong-Yu ^{[6
]}

Liu, Jin-Song ^{[1
]}

Lee, Kuo-Hsiung ^{[2
,5
]}

机构：

[1] Anhui Univ Chinese Med, Sch Pharm, Anhui Key Lab Modern Chinese Mat Med, Hefei 230012, Anhui, Peoples R China

[2] Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA

[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[4] China Med Univ, Dept Pharm, Coll Pharm, Taichung 40402, Taiwan

[5] China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung 40402, Taiwan

[6] Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 12期

关键词：

CONSTITUENTS; TERPENOIDS; RHIZOMES;

D O I：

10.1021/acs.jnatprod.9b00693

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In a study of the potential anti-inflammatory constituents from Kalimeris shimadae, six new sesquiterpenes, kalshinoids A F (1-6), together with 21 known compounds (7-27), were isolated. The structures and absolute configurations of the new compounds were discerned from extensive spectroscopic analysis, and the absolute configurations of kalshinoids A, B, E, and F were established by ECD calculations. Furthermore, the identified compounds were tested for antiinflammatory activity as assessed by inhibition of tumor necrosis factor-alpha (TNF-alpha) in THP-1 cells. Three sesquiterpenes [kalshinoid F, 4(15)-eudesmen-1 beta,7,11-triol, and 4 alpha,10 alpha,11-trihydroxy-1 beta H,5 beta H-guai-7(8)-ene] reduced levels of TNF-alpha in lipopolysaccharide-stimulated THP-1 cells in a concentration dependent manner and were more potent than dexamethasone. These natural sesquiterpenes merit further investigation as possible anti-inflammatory agents.

引用

页码：3372 / 3378

页数：7

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