Combination therapy with amphotericin B lipid complex and caspofungin acetate of disseminated zygomycosis in diabetic ketoacidotic mice

被引：136
作者：
Spellberg, B
Fu, Y
Edwards, JE
Ibrahim, AS
机构：
[1] St Johns Cardiovasc Res Ctr, Harbor UCLA Res & Educ Inst, Dept Med, Div Infect Dis, Torrance, CA 90502 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 02期
关键词：
D O I：
10.1128/AAC.49.2.830-832.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We studied the combination of amphotericin B lipid complex (ABLC) and caspofungin in mice with disseminated Rhizopus oryzae. Combination therapy improved survival compared to that of mice given monotherapy and that of untreated controls (P < 0.05) but did not improve organ clearance. In addition, prophylactic combination therapy was not more effective than prophylactic ABLC alone.
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页码：830 / 832
页数：3
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