Developmental differences in psychological adjustment and health-related quality of life in pediatric cancer patients

The aims of this study were to investigate: (a) age differences in psychological adjustment (PA) and health-related quality of life (HRQOL) in pediatric cancer patients, and (b) identify predictors of PA and HRQOL. The sample included preschool, school age, and adolescent patients. Data were obtained at 3 (n = 69), 9 (n = 47), and 15 (n = 44) months after diagnosis, using standardized measures completed by the mother. Measures assessed the children's psychological adjustment (PA), health-related quality of life (HRQOL), temperament and maternal psychological adjustment. Age at diagnosis significantly affected both PA and HRQOL. At 3 months post-diagnosis, preschoolers had more externalizing behavior problems than did adolescents. Preschoolers had better HRQOL than adolescents at all 3 assessments. Maternal adjustment and child's temperament scores were the best predictors of PA; age was the best predictor of HRQOL. The results of this study suggest that preschoolers with cancer are at risk for behavior problems and adolescents are at risk for poor HRQOL. The results also highlight the importance of multi-factor models in predicting children's PA and HRQOL.