Synthesis and anticancer activity of new pyrrolocarbazoles and pyrrolo-β-carbolines

被引：85
作者：
Laronze, M
Boisbrun, M
Léonce, S
Pfeiffer, B
Renard, P
Lozach, O
Meijer, L
Lansiaux, A
Bailly, C
Sapi, J
Laronze, JY
机构：
[1] Fac Pharm Reims, CNRS, F-51096 Reims, France
[2] Inst Rech Servier, F-78290 Croissy Sur Seine, France
[3] CNRS, Biol Stn, F-29682 Roscoff, France
[4] INSERM, U524, Lab Pharmacol Antitumorale Ctr Oscar Lambret, IRCL, F-59045 Lille, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 06期
关键词：
pyrrolocarbazoles; pyrrolo-beta-carbolines; cytotoxicity; DNA-binding;
D O I：
10.1016/j.bmc.2004.12.045
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
'Bended' 1, 3 or 'linear' 2 pyrrolidino-fused (aza)carbazoles were prepared and screened towards a few cancer-related targets. Whereas 'bended' derivatives I and 3 proved to be weakly toxic, several members of the 'linear' family strongly interact with DNA, especially derivative 28a. (c) 2005 Elsevier Ltd. All rights reserved.
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收藏
页码：2263 / 2283
页数：21
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