Advances in the genotypic diagnosis of cytomegalovirus antiviral drug resistance

被引：77
作者：
Chou, Sunwen [1 ,2 ]
机构：
[1] Oregon Hlth & Sci Univ, Div Infect Dis, Portland, OR 97201 USA
[2] Dept Vet Affairs Med Ctr, Portland, OR USA
来源：
ANTIVIRAL RESEARCH | 2020年 / 176卷
基金：
美国国家卫生研究院;
关键词：
STEM-CELL TRANSPLANTATION; UL97; KINASE; IN-VITRO; GANCICLOVIR RESISTANCE; PHENOTYPIC CHARACTERIZATION; FOSCARNET RESISTANCE; TERMINASE COMPLEX; PROTEIN-KINASE; MUTATIONS; LETERMOVIR;
D O I：
10.1016/j.antiviral.2020.104711
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cytomegalovirus (CMV) drug resistance mutation maps are updated with recent information for polymerase inhibitors, the terminase inhibitor letermovir and the UL97 kinase inhibitor maribavir. Newly mapped mutations and their phenotypes provide more detail on cross-resistance properties and suggest the need to expand the CMV gene regions covered in diagnostic testing. Next-generation deep sequencing technology offers a more sensitive, higher resolution view of emerging antiviral resistance and is recommended for use in clinical trials. Issues of standardization and diagnostic utility in comparison with traditional Sanger sequencing remain unresolved. Quality control is important for the accurate and reproducible detection of mutant viral populations in clinical specimens.
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页数：10
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