Gender-Specific Association of Serum Uric Acid and Pulmonary Function: Data from the Korea National Health and Nutrition Examination Survey

被引:10
|
作者
Jeong, Hyemin [1 ]
Baek, Sun-Young [2 ]
Kim, Seon-Woo [2 ]
Park, Eun-Jung [3 ]
Kim, Hyungjin [4 ]
Lee, Jaejoon [4 ]
Jeon, Chan-Hong [1 ]
机构
[1] Soonchunhyang Univ, Bucheon Hosp, Coll Med, Div Rheumatol,Dept Internal Med, 170 Jomaru Ro, Bucheon 14584, South Korea
[2] Samsung Med Ctr, Biostat & Clin Epidemiol Ctr, 81 Irwon Ro, Seoul 06351, South Korea
[3] Natl Med Ctr, Dept Internal Med, Div Rheumatol, 245 Eulji Ro, Seoul 04564, South Korea
[4] Sungkyunkwan Univ, Dept Internal Med, Div Rheumatol, Sch Med,Samsung Med Ctr, 81 Irwon Ro, Seoul 06351, South Korea
来源
MEDICINA-LITHUANIA | 2021年 / 57卷 / 09期
关键词
uric acid; nutrition surveys; lung; respiratory function tests; SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS; HYPOXIA; RISK; GOUT;
D O I
10.3390/medicina57090953
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Objectives: Hyperuricemia is associated with several comorbidities. The association between uric acid (UA) and pulmonary function is still a controversial issue. This study evaluated the gender-specific association of serum UA and pulmonary function. Materials and Methods: A total of 3177 (weighted n = 19,770,902) participants aged 40 years or older were selected from the 2016 Korean National Health and Nutrition Examination Survey and included. Results: Female participants with hyperuricemia were older than participants with normouricemia. Body mass index (BMI), mean arterial pressure (MAP), hemoglobin A1c (HbA1c), and estimated glomerular filtration rate (eGFR) were significantly associated with UA levels in both males and females. Hyperuricemia and increase in UA quartile were significantly associated with decreased forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) in females after adjustment for age, income, region, education, marital status, alcohol consumption, smoking, BMI, MAP, HbA1c, and eGFR. There was no significant association between UA levels and lung function in males. After additional adjustment for respiratory disease including pulmonary tuberculosis, asthma, and lung cancer, the association between hyperuricemia and decreased FEV1 and FVC in females was revealed. Conclusions: Hyperuricemia was associated with decreased FVE1 and FVC in the female general population.
引用
收藏
页数:10
相关论文
共 50 条
  • [41] Relationship between pulmonary function and bone mineral density in the Korean National Health and Nutrition Examination Survey
    Lee, In Seon
    Leem, Ah Young
    Lee, Sang Hoon
    Rhee, Yumie
    Ha, Yoon
    Kim, Young Sam
    KOREAN JOURNAL OF INTERNAL MEDICINE, 2016, 31 (05) : 899 - 909
  • [42] The Relationship Between Nocturia and Mortality: Data From the National Health and Nutrition Examination Survey
    Moon, Shinje
    Kim, Yoon Jung
    Chung, Hye Soo
    Yu, Jae Myung
    Park, Il In
    Park, Sung Gon
    Pak, Sahyun
    Kwon, Ohseong
    Lee, Young Goo
    Cho, Sung Tae
    INTERNATIONAL NEUROUROLOGY JOURNAL, 2022, 26 (02) : 144 - 152
  • [43] Vegetable intake in Korea: data from the Korean National Health and Nutrition Examination Survey 1998, 2001 and 2005
    Lee, Jung-Sug
    Kim, Jeongseon
    BRITISH JOURNAL OF NUTRITION, 2010, 103 (10) : 1499 - 1506
  • [44] Effect of Serum Ferritin on the Association Between Coffee Intake and Hyperuricemia Among American Women: The National Health and Nutrition Examination Survey
    Agoons, Dayawa D.
    Agoons, Batakeh B.
    Kaze, Arnaud D.
    Komanduri, Saketram
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2021, 13 (03)
  • [45] Age-specific association between body mass index and depression: The Korea National Health and Nutrition Examination Survey 2014
    Oh, J.
    Chae, J-H
    Kim, T-S
    INTERNATIONAL JOURNAL OF OBESITY, 2018, 42 (03) : 327 - 333
  • [47] Gender Difference in the Association of Hyperuricemia with Insulin Resistance and beta-cell Function in Nondiabetic Korean Adults: The 2019 Korea National Health and Nutrition Examination Survey
    Seong, Jeong Min
    Gi, Mi Young
    Cha, Ju Ae
    Sung, Hyun Ho
    Park, So Young
    Park, Cho Hee
    Yoon, Hyun
    ENDOCRINE RESEARCH, 2023, 48 (01) : 1 - 8
  • [48] Impact of metformin on serum prostate-specific antigen levels: Data from the national health and nutrition examination survey 2007 to 2008
    Park, Jee Soo
    Lee, Kwang Suk
    Ham, Won Sik
    Chung, Byung Ha
    Koo, Kyo Chul
    MEDICINE, 2017, 96 (51)
  • [49] Serum lipid levels in depression and suicidality: The Korea National Health and Nutrition Examination Survey (KNHANES) 2014
    Oh, Jihoon
    Kim, Tae-Suk
    JOURNAL OF AFFECTIVE DISORDERS, 2017, 213 : 51 - 58
  • [50] Association of meal frequency with metabolic syndrome in Korean adults: from the Korea National Health and Nutrition Examination Survey (KNHANES)
    Jung, Chan-Hee
    Lee, Ji Sung
    Ahn, Hee Jung
    Choi, Jin-Sun
    Noh, Min Young
    Lee, Ji Jeung
    Lee, Eun Young
    Lim, Jeong Hyun
    Lee, Young Ran
    Yoon, So Yoon
    Kim, Chong Hwa
    Cho, Dong-Hyeok
    Choi, Young Sik
    Choi, Kyung Mook
    DIABETOLOGY & METABOLIC SYNDROME, 2017, 9