Gender-Specific Association of Serum Uric Acid and Pulmonary Function: Data from the Korea National Health and Nutrition Examination Survey

被引:10
|
作者
Jeong, Hyemin [1 ]
Baek, Sun-Young [2 ]
Kim, Seon-Woo [2 ]
Park, Eun-Jung [3 ]
Kim, Hyungjin [4 ]
Lee, Jaejoon [4 ]
Jeon, Chan-Hong [1 ]
机构
[1] Soonchunhyang Univ, Bucheon Hosp, Coll Med, Div Rheumatol,Dept Internal Med, 170 Jomaru Ro, Bucheon 14584, South Korea
[2] Samsung Med Ctr, Biostat & Clin Epidemiol Ctr, 81 Irwon Ro, Seoul 06351, South Korea
[3] Natl Med Ctr, Dept Internal Med, Div Rheumatol, 245 Eulji Ro, Seoul 04564, South Korea
[4] Sungkyunkwan Univ, Dept Internal Med, Div Rheumatol, Sch Med,Samsung Med Ctr, 81 Irwon Ro, Seoul 06351, South Korea
来源
MEDICINA-LITHUANIA | 2021年 / 57卷 / 09期
关键词
uric acid; nutrition surveys; lung; respiratory function tests; SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS; HYPOXIA; RISK; GOUT;
D O I
10.3390/medicina57090953
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Objectives: Hyperuricemia is associated with several comorbidities. The association between uric acid (UA) and pulmonary function is still a controversial issue. This study evaluated the gender-specific association of serum UA and pulmonary function. Materials and Methods: A total of 3177 (weighted n = 19,770,902) participants aged 40 years or older were selected from the 2016 Korean National Health and Nutrition Examination Survey and included. Results: Female participants with hyperuricemia were older than participants with normouricemia. Body mass index (BMI), mean arterial pressure (MAP), hemoglobin A1c (HbA1c), and estimated glomerular filtration rate (eGFR) were significantly associated with UA levels in both males and females. Hyperuricemia and increase in UA quartile were significantly associated with decreased forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) in females after adjustment for age, income, region, education, marital status, alcohol consumption, smoking, BMI, MAP, HbA1c, and eGFR. There was no significant association between UA levels and lung function in males. After additional adjustment for respiratory disease including pulmonary tuberculosis, asthma, and lung cancer, the association between hyperuricemia and decreased FEV1 and FVC in females was revealed. Conclusions: Hyperuricemia was associated with decreased FVE1 and FVC in the female general population.
引用
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页数:10
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