Familial History of Autoimmune Disorders Among Patients With Pediatric Multiple Sclerosis

被引：7

作者：

Greenberg, Benjamin M. ^{[1
]}

Casper, Theron Charles ^{[2
]}

Mar, Soe S. ^{[2
,3
]}

Ness, Jayne M. ^{[4
]}

Plumb, Patricia ^{[5
]}

Liang, Shannon ^{[6
]}

Goyal, Manu ^{[6
]}

Weinstock-Guttman, Bianca ^{[7
]}

Rodriguez, Moses ^{[8
]}

Aaen, Gregory S. ^{[9
]}

Belman, Anita ^{[10
]}

Barcellos, Lisa F. ^{[11
]}

Rose, John W. ^{[12
]}

Gorman, Mark P. ^{[13
]}

Benson, Leslie A. ^{[13
]}

Candee, Meghan ^{[14
]}

Chitnis, Tanuja ^{[15
]}

Harris, Yolanda C. ^{[16
]}

Kahn, Ilana L. ^{[17
]}

Roalstad, Shelly

Hart, Janace ^{[18
]}

Lotze, Timothy E. ^{[19
]}

Rensel, Mary ^{[20
]}

Rubin, Jennifer P. ^{[21
]}

Schreiner, Teri L. ^{[22
]}

Tillema, Jan-Mendelt ^{[8
]}

Waldman, Amy Tara ^{[23
]}

Krupp, Lauren ^{[24
]}

Graves, Jennifer ^{[25
]}

Drake, Kaylea ^{[2
]}

Waubant, Emmanuelle ^{[18
]}

机构：

[1] Univ Texas Southwestern, Dept Neurol, Dept Pediat, Dallas, TX 75390 USA

[2] Univ Utah, Data Coordinating & Anal Ctr, Salt Lake City, UT USA

[3] Washington Univ, St Louis, MO 63110 USA

[4] Univ Alabama Birmingham, Birmingham, AL USA

[5] Univ Texas Southwestern, Dept Neurol, Dallas, TX USA

[6] Washington Univ, Dept Radiol, St Louis, MO 63110 USA

[7] SUNY Buffalo, Jacobs Pediat Multiple Sclerosis Ctr, Buffalo, NY USA

[8] Mayo Clin, Pediat Multiple Sclerosis Ctr, Rochester, MN USA

[9] Loma Linda Univ, Childrens Hosp, Pediat Multiple Sclerosis Ctr, Loma Linda, CA 92350 USA

[10] Stony Brook Univ Hosp, Lourie Ctr Pediat Multiple Sclerosis, Stony Brook, NY USA

[11] Univ Calif Berkeley, Epidemiol, Berkeley, CA 94720 USA

[12] Univ Utah, Dept Neurol, Salt Lake City, UT USA

[13] Boston Childrens Hosp, Pediat Multiple Sclerosis & Related Disorders Pro, Boston, MA USA

[14] Univ Utah, Primary Childrens Hosp, Salt Lake City, UT USA

[15] Massachusetts Gen Hosp, Partners Pediat Multiple Sclerosis Ctr, Boston, MA 02114 USA

[16] Univ Alabama Birmingham, Childrens Hosp Alabama, Ctr Pediat Onset Demyelinating Dis, Birmingham, AL USA

[17] Childrens Natl Med Ctr, Washington, DC 20010 USA

[18] Univ Calif San Francisco, Pediat Multiple Sclerosis Ctr, San Francisco, CA 94143 USA

[19] Texas Childrens Hosp, Baylor Coll Med, Blue Bird Circle Clin Multiple Sclerosis, Houston, TX 77030 USA

[20] Cleveland Clin, Mellen Ctr Multiple Sclerosis, Cleveland, OH 44106 USA

[21] Lurie Childrens Hosp Chicago, Chicago, IL USA

[22] Univ Colorado Denver, Childrens Hosp Colorado, Rocky Mt Multiple Sclerosis Ctr, Aurora, CO USA

[23] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

[24] NYU, Pediat Multiple Sclerosis Ctr, New York, NY 10003 USA

[25] Univ Calif San Diego, Pediat Multiple Sclerosis Ctr, La Jolla, CA 92093 USA

来源：

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION | 2021年 / 8卷 / 05期

关键词：

RISK-FACTORS; VITAMIN-D; EPIDEMIOLOGY;

D O I：

10.1212/NXI.0000000000001049

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Objective The objective of this study was to determine whether family members of patients with pediatric multiple sclerosis (MS) have an increased prevalence of autoimmune conditions compared with controls. Methods Data collected during a pediatric MS case-control study of risk factors included information about various autoimmune diseases in family members. The frequency of these disorders was compared between cases and controls. Results There was an increased rate of autoimmune diseases among family members of pediatric MS cases compared with controls with first-degree history of MS excluded (OR = 2.27, 95% CI 1.71-3.01, p < 0.001). There was an increased rate of MS among second-degree relatives of pediatric MS cases compared with controls (OR = 3.47, 95% CI 1.36-8.86, p = 0.009). The OR for MS was 2.64 when restricted to maternal relatives and 6.37 when restricted to paternal relatives. Discussion The increased rates of autoimmune disorders, including thyroid disorders and MS among families of patients with pediatric MS, suggest shared genetic factors among families with children diagnosed with pediatric MS.

引用

页数：8

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